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  4. Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

Animals, 2021 · DOI: 10.3390/ani11082442 · Published: August 19, 2021

Spinal Cord InjuryVeterinary MedicineNeurorehabilitation

Simple Explanation

A non-invasive neurorehabilitation multimodal protocol (NRMP) may be applicable to chronic T3-L3 dogs 3 months after undergoing surgery for acute Intervertebral Disc Disease (IVDD) Hansen type I; this protocol has been shown to be safe, feasible, and potentially effective at improving ambulation in both open field score (OFS) 0 and OFS 1 dogs. Thus, the present case series study aimed to demonstrate that an NRMP could contribute to a functional treatment possibly based on synaptic and anatomic reorganization of the spinal cord. This case series clinical study intends to verify whether a neurorehabilitation multimodal protocol (NRMP) is a safe and feasible therapeutic protocol to be applied in SCI chronic dogs and to assess whether this NRMP allows a positive neurological evolution until ambulation and within a time period that is clinically acceptable.

Study Duration
90 days maximum
Participants
16 chronic post-surgical IVDD Hansen type I dogs
Evidence Level
Case Series

Key Findings

  • 1
    In the Deep Pain Perception (DPP)+ dogs, 100% recovered ambulation within a mean period of 47 days, reaching OFS ≥11, which suggests that a longer period of time is needed for recovery.
  • 2
    Of the DPP−dogs admitted, all achieved a flexion/extension locomotor pattern within 30 days, and after starting the 4-AP, two dogs were discharged at outcome day 45, with 78% obtaining Spinal Reflex Locomotion (SRL) and automatic micturition within a mean period of 62 days.
  • 3
    After the NRMP, ambulatory status was achieved in 88% (14/16) of dogs, without concurrent events.

Research Summary

This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP−(n = 9) and OFS 1/DPP+ (n = 7). After admission, the dogs were redirected to a neurorehabilitation consultation and evaluated based on their history and neurorehabilitation examination (mental status, posture, OFS gait, postural reactions, peripheral spinal reflexes, cutaneous trunci muscle reflex, spinal cord palpation, and pain perception). Thus, an NRMP may be an important therapeutic option to reduce the need for euthanasia in the clinical setting.

Practical Implications

Clinical Practice

NRMP (neurorehabilitation multimodal protocol) can be considered as a safe and feasible therapeutic approach for chronic post-surgical SCI dogs.

Reduce Euthanasia

Employing NRMP may reduce the need for euthanasia in clinical settings for dogs with chronic SCI.

Further Research

More controlled studies are needed to explore the association between NRMP, stem cell administration, and/or pharmacological management with 4-AP.

Study Limitations

  • 1
    Small number of dogs
  • 2
    Lack of control cases
  • 3
    Appearance of SRL (Spinal Reflex Locomotion) may have been due to spontaneous recovery, coincidental, or due to the contribution of 4-AP

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