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  4. Estimates of the precision of regional and whole body composition by dual-energy x-ray absorptiometry in persons with chronic spinal cord injury

Estimates of the precision of regional and whole body composition by dual-energy x-ray absorptiometry in persons with chronic spinal cord injury

Spinal Cord, 2018 · DOI: 10.1038/s41393-018-0079-x · Published: October 1, 2018

Spinal Cord InjuryPhysiologyMedical Imaging

Simple Explanation

This study examines how reliably a DXA scan can measure body composition in people with spinal cord injuries (SCI). DXA scans use X-rays to measure fat, lean mass, and bone density. The study looks at both short-term precision (scans taken on the same day) and long-term precision (scans taken weeks apart) to see how consistent the measurements are. Understanding the precision of DXA scans is important for tracking changes in body composition over time, especially when studying the effects of exercise or other interventions in people with SCI.

Study Duration
4 weeks
Participants
24 individuals with SCI (short-term), 22 individuals with SCI (long-term)
Evidence Level
Longitudinal design

Key Findings

  • 1
    Short-term precision: The RMS-CV% for each region did not exceed 5.6%, 2.7%, 3.8%, 6.5%, 5.8% and 2.3% for arms, legs, trunk, android and gynoid regions and total body mass, respectively.
  • 2
    Long-term precision: The RMS-CV% for each region did not exceed 6.0%, 3.0%, 4.4%, 8.2%, 3.4% and 2.0% for arms, legs, trunk, android, gynoid and total body mass.
  • 3
    The interclass-correlation coefficient in the long-term precision group demonstrated excellent linear agreement between repeat scans for all regions (r> 0.97).

Research Summary

This study evaluated the reproducibility of total and regional DXA-derived body composition values in individuals with spinal cord injury (SCI). The study assessed both short-term (same day) and long-term (4-week interval) precision of DXA scans in measuring body composition in persons with SCI. The precision error of total body composition variables in the SCI cohort was similar to those reported in nondisabled individuals, while regional body composition compartments showed higher precision errors, consistent with reports in the general population.

Practical Implications

Informed Clinical Trials

The precision data can be used to calculate appropriate sample sizes for future clinical trials evaluating interventions aimed at improving body composition in SCI.

Improved Interpretation of DXA Results

The study provides context for interpreting DXA results in SCI patients, especially regarding regional body composition changes.

Standardized DXA Procedures

Highlights the importance of standardized DXA scanning protocols and technician training to minimize variability and improve precision.

Study Limitations

  • 1
    Relatively small sample size
  • 2
    Lack of statistical power to calculate the least significant change (LSC) of the total body composition variables.
  • 3
    Only men with SCI were included

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