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  4. Ergogenic effects of spinal cord stimulation on exercise performance following spinal cord injury

Ergogenic effects of spinal cord stimulation on exercise performance following spinal cord injury

Frontiers in Neuroscience, 2024 · DOI: 10.3389/fnins.2024.1435716 · Published: August 29, 2024

Spinal Cord InjuryNeurorehabilitationRehabilitation

Simple Explanation

Spinal cord injury (SCI) often leads to cardiovascular issues during exercise due to disrupted nerve signals. This study explores whether spinal cord stimulation (SCS) can improve exercise performance in individuals with SCI. The study compared two types of SCS: epidural (ESCS, invasive) and transcutaneous (TSCS, non-invasive), against sham conditions to see their impact on cardiovascular responses and upper-body exercise performance in SCI patients. The findings suggest that both ESCS and TSCS can improve blood pressure and cardiac function, leading to enhanced exercise performance in individuals with SCI, offering potential as ergogenic aids and fatigue reduction during daily activities.

Study Duration
Not specified
Participants
7 males with chronic, motor-complete SCI (C6-T4) for mapping; 4 (2 ESCS, 2 TSCS) completed exercise testing
Evidence Level
Level IV; Case Series

Key Findings

  • 1
    CV-SCS increased blood pressure and predicted left ventricular cardiac contractility and total peripheral resistance at rest.
  • 2
    During exercise, CV-SCS increased time to exhaustion and peak oxygen pulse (a surrogate for stroke volume), relative to SHAM-SCS.
  • 3
    Ratings of perceived exertion also tended to be lower with CV-SCS than SHAM-SCS.

Research Summary

This study investigated the effects of cardiovascular-optimised epidural spinal cord stimulation (ESCS) and transcutaneous spinal cord stimulation (TSCS) on modulating cardiovascular responses and improving submaximal upper-body exercise performance in individuals with SCI. The results showed that both ESCS and TSCS increased resting blood pressure and predicted left ventricular cardiac contractility and total peripheral resistance. During exercise, both ESCS and TSCS improved time to exhaustion and peak oxygen pulse, suggesting that both approaches could be promising ergogenic aids for individuals with SCI.

Practical Implications

Rehabilitation Tool

TSCS could be used as a therapeutic tool to stimulate meaningful physiological adaptations during exercise training or rehabilitation.

Improved Exercise Performance

ESCS and TSCS can mitigate resting hypotension and improve acute upper-body exercise performance in individuals with SCI.

Reduced Fatigue

The lower RPE during exercise trials may have an important translation to individuals using SCS to minimize fatigue during activities of daily living.

Study Limitations

  • 1
    Small sample size warrants adequately powered studies to corroborate findings.
  • 2
    Difficult to identify ventilatory thresholds in individuals with higher neurological levels of injury.
  • 3
    Limitations in filtering TSCS artefacts from the trunk EMG signals restricted our understanding of trunk muscle activation.

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