Epidural Stimulation and Resistance Training (REST-SCI) for Overground Locomotion After Spinal Cord Injury: Randomized Clinical Trial Protocol

This study aims to improve walking ability in people with complete spinal cord injuries using a combination of exoskeleton-assisted walking (EAW), epidural stimulation (ES), and resistance training (RT). The researchers will compare this combined approach to EAW with delayed ES and no RT. Participants will be divided into two groups: one receiving EAW+ES+RT immediately, and the other receiving EAW only initially, followed by delayed ES. The study will assess motor control, cardiovascular health, body composition, and bladder function to see if the combined approach is more effective. The study involves several phases, including screening, implantation of an epidural stimulator, and a 12-month training program. Measurements are taken at baseline, 6 months, and 12 months to track progress and compare outcomes between the two groups.

• 1
  The restoration of locomotion with ES and EAW may result in a reduction in psychosocial, cardiovascular, and metabolic bladder parameters and socioeconomic burden.
• 2
  The addition of the resistance training paradigm may further augment the outcomes of ES on motor function in persons with SCI.
• 3
  Percutaneous SCES appears to be a feasible and safe rehabilitation approach for the restoration of motor function in persons with SCI.