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  4. Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review

Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review

Internal Medicine, 2023 · DOI: 10.2169/internalmedicine.9580-22 · Published: January 1, 2023

Cardiovascular ScienceOncologyNeurology

Simple Explanation

This is a case report about a 14-year-old boy who was diagnosed with acute myeloid leukemia (AML) after experiencing spinal cord compression. The compression was due to a mass that had formed outside of the spinal cord but within the epidural space, which is a rare way for AML to first appear. The boy had symptoms like back pain, weakness in his legs, and problems with bladder and bowel control. Doctors performed surgery to remove the mass and then started chemotherapy to treat the leukemia. While the chemotherapy was successful in eliminating the leukemia, the boy still had some neurological problems afterward. The report also includes a review of other similar cases in medical literature, highlighting that spinal cord compression from AML can worsen quickly. This suggests that it's very important to diagnose and treat it as soon as possible to avoid lasting nerve damage.

Study Duration
Not specified
Participants
A 14-year-old boy
Evidence Level
Case Report and Literature Review

Key Findings

  • 1
    A rare presentation of AML in a 14-year-old boy was spinal cord compression due to an epidural mass.
  • 2
    Emergency laminectomy and resection of the mass were performed followed by chemotherapy, leading to complete remission of AML, however, neurological sequelae persisted.
  • 3
    Spinal cord compression from epidural AML involvement can progress rapidly, emphasizing the need for prompt diagnosis and intervention.

Research Summary

This case report details a 14-year-old boy presenting with spinal cord compression as the initial manifestation of acute myeloid leukemia (AML). The compression was caused by an epidural mass, which was surgically removed followed by chemotherapy. A literature review identified 23 similar cases, indicating that spinal cord compression due to AML or myeloid sarcoma can progress rapidly. Early diagnosis and intervention are crucial to prevent neurological sequelae in such cases.

Practical Implications

Prompt Diagnosis

Clinicians should consider AML in the differential diagnosis of spinal cord compression, especially in patients with a history of malignancy or suggestive symptoms.

Rapid Intervention

Due to the rapid progression of spinal cord compression in AML, prompt intervention, including surgery and/or chemotherapy, is essential to minimize neurological damage.

Awareness of Rare Presentations

This case highlights the importance of recognizing rare presentations of AML to ensure timely and appropriate management.

Study Limitations

  • 1
    Single case report limits generalizability
  • 2
    Literature review limited to English articles from 2000-2021
  • 3
    Neurological outcomes were described in only 11 patients in the literature review

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