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  4. Effects of non‑invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta‑analysis

Effects of non‑invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta‑analysis

Journal of NeuroEngineering and Rehabilitation, 2023 · DOI: 10.1186/s12984-023-01129-4 · Published: January 7, 2023

Spinal Cord InjuryNeurologyNeurorehabilitation

Simple Explanation

This study investigates the use of non-invasive brain stimulation (NIBS) techniques like rTMS and tDCS to improve motor function in people with spinal cord injury (SCI). NIBS aims to modulate brain activity to enhance recovery. The study combined data from multiple clinical trials to assess the effectiveness of NIBS on various aspects of motor function, such as lower and upper extremity strength, balance, and spasticity. The results suggest that NIBS may positively affect lower extremity strength and balance in SCI patients, but more research is needed to optimize its application and confirm long-term benefits.

Study Duration
Not specified
Participants
225 participants
Evidence Level
Systematic review and meta-analysis of 14 randomized control trials

Key Findings

  • 1
    NIBS shows potential for improving lower extremity strength in SCI patients (SMD = 0.58, 95% CI = 0.02–1.14, P = 0.004).
  • 2
    NIBS may improve balance in SCI patients (SMD = 0.64, 95% CI = 0.05–1.24, P = 0.03).
  • 3
    NIBS can decrease spasticity in SCI patients (SMD = − 0.64, 95% CI = − 1.20 to − 0.03, P = 0.04).

Research Summary

This systematic review and meta-analysis examined the effects of non-invasive brain stimulation (NIBS) on motor function recovery in patients with spinal cord injury (SCI). The study found that NIBS appears to have positive effects on lower extremity strength, balance, and spasticity, but not on upper extremity motor ability or functional mobility. The authors conclude that further high-quality clinical trials are needed to optimize NIBS parameters and support its use in clinical practice for SCI patients.

Practical Implications

Clinical Practice

NIBS may be considered as a complementary treatment to conventional therapies for improving lower extremity motor function in SCI patients.

Future Research

Future studies should focus on optimizing NIBS parameters, such as stimulation type, frequency, and duration, to maximize its effectiveness.

Personalized Treatment

Further research is needed to identify which SCI patients are most likely to benefit from NIBS based on factors such as injury severity, lesion level, and time since injury.

Study Limitations

  • 1
    Methodological quality of some included trials was low.
  • 2
    The review is restricted to short-term effects of NIBS.
  • 3
    Only articles published in English were included.

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