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  4. Effects of different transcranial magnetic stimulations on neuropathic pain after spinal cord injury

Effects of different transcranial magnetic stimulations on neuropathic pain after spinal cord injury

Frontiers in Neurology, 2023 · DOI: 10.3389/fneur.2023.1141973 · Published: July 13, 2023

NeurologyPain ManagementRehabilitation

Simple Explanation

This study investigates the effectiveness of different types of transcranial magnetic stimulation (TMS) on neuropathic pain in individuals with spinal cord injury (SCI). TMS is a non-invasive technique that stimulates the brain using magnetic pulses to relieve pain. The study compares intermittent theta burst stimulation (iTBS), 10 Hz repetitive TMS (rTMS), and a combination of both (iTBS + rTMS). The researchers measured pain levels, depression, and sleep quality before, during, and after the treatment. The results suggest that all three stimulation methods can help reduce pain, depression, and improve sleep quality in individuals with SCI. However, iTBS used as a priming stimulus was more effective than iTBS alone in relieving neuropathic pain.

Study Duration
August 2020 and June 2021
Participants
37 individuals with SCI
Evidence Level
Clinical Trial

Key Findings

  • 1
    All three modalities (iTBS, rTMS, iTBS + rTMS) significantly improved pain, depression, and sleep quality after 4 weeks of stimulation in individuals with SCI.
  • 2
    Significant pain improvement was observed after 4 weeks of stimulation, but not after 1 week.
  • 3
    iTBS as a priming stimulus was more effective than iTBS alone in treating neuropathic pain.

Research Summary

This study evaluated the effects of iTBS, rTMS, and iTBS+rTMS on neuropathic pain, depression, and sleep quality in individuals with SCI. Thirty-seven participants were randomly assigned to one of three groups and received stimulation 5 days a week for 4 weeks. The results showed significant improvements in pain (VAS scores), depression (HAM-D scores), and sleep quality (PSQI scores) after 4 weeks of stimulation in all three groups. Comparison of the three modalities revealed that iTBS as a priming stimulus was more effective than iTBS alone in relieving neuropathic pain, suggesting potential optimization of treatment protocols.

Practical Implications

Clinical Practice

Clinicians may consider using iTBS as a priming stimulus for rTMS to enhance pain relief in patients with neuropathic pain after SCI.

Treatment Efficiency

The study suggests that iTBS sessions can be completed in less time than 10 Hz rTMS, potentially reducing the burden on patients without compromising treatment effectiveness.

Personalized Treatment

Recognizing the unique needs of each patient, clinicians should consider iTBS as a preferred modality for certain types of patients or conditions based on the study's insights.

Study Limitations

  • 1
    Small sample size
  • 2
    Lack of a follow-up to assess the long-term effects of the stimulation
  • 3
    Potential type II errors due to the rarity of individuals with SCI

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