Effects of different interventions on animal models of ischemic stroke Protocol for an overview and a network meta-analysis

Medicine, 2019 · DOI: http://dx.doi.org/10.1097/MD.0000000000015384 · Published: April 1, 2019

Simple Explanation

Ischemic stroke is a major global health problem that often results in lasting disability or death. This study aims to use overview and network meta-analysis to find effective interventions for reducing infarct volume and improving neurobehavioral scores in animal models of ischemic stroke. The researchers will conduct a thorough search of PubMed and Embase for relevant systematic reviews. They will then assess the quality of these reviews and the risk of bias in randomized controlled trials (RCTs) included in those reviews. The study will use infarct volume and neurobehavioral score as primary and secondary outcomes, respectively. The results will be submitted for publication in a peer-reviewed journal.

Study Duration

Not specified

Participants

Animal models of ischemic stroke

Evidence Level

Systematic Review and Network Meta-Analysis Protocol

Key Findings

1
This study aims to identify the more effective intervention for infarct volume in animal models of ischemic stroke.
2
The study also aims to identify the more effective intervention for neurobehavioral score in animal models of ischemic stroke.
3
The study can provide a reference for further clinical practice and be compared with clinical trial results to obtain a more credible therapeutic effect.

Research Summary

This protocol outlines a plan to conduct an overview and network meta-analysis (NMA) to evaluate the effectiveness of different interventions in animal models of ischemic stroke. The study will involve a systematic literature search, quality assessment of included reviews, and data analysis using standardized mean difference (SMD) and network meta-analysis techniques. The goal is to identify the optimal intervention that can provide a reference for clinical practice and be compared with clinical trial results.

Practical Implications

Clinical Practice

The study aims to provide a reference for further clinical practice by identifying the most effective interventions in animal models.

Clinical Trials

The results can be compared with clinical trial results to obtain a more credible therapeutic effect of the interventions.

Animal Research

The comprehensive analysis of animal model experimental results can help find the most effective interventions in animal models of cerebral ischemia.

Study Limitations

1
The natural gap between animals and people may lead to inconsistencies between animal model results and clinical trials.
2
Implementation bias in animal model experiments can affect the authenticity of test results.
3
The therapeutic measures found in animal models need to be interpreted cautiously in clinical application.

Your Feedback

Was this summary helpful?

Back to Neurology