Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury

This study explores the relationship between spinal cord structure and functional assessments after spinal cord injury in dogs using diffusion tensor imaging (DTI). DTI is a technique that can quantify pathological damage in the spinal cord's white and gray matter. A spinal cord contusion-impactor was used to injure the T10 spinal cord of beagles, and changes were observed using DTI. The Texas Spinal Cord Injury Score (TSCIS) was used to assess neurological function at various time points after the injury. The study found a high correlation between the apparent diffusion-coefficient value and the Texas Spinal Cord Injury Score, suggesting that this value could accurately predict the recovery of neurological function after spinal cord injury.

• 1
  Fractional anisotropy values decreased after spinal cord injury, while the apparent diffusion coefficient, mean diffusivity, and radial diffusivity initially decreased and then increased over time.
• 2
  The apparent diffusion-coefficient value was highly associated with the Texas Spinal Cord Injury Score for the whole spinal cord, white matter, and gray matter.
• 3
  The apparent diffusion-coefficient value for white matter had the highest and most significant correlation with neurological function, suggesting its potential for predicting recovery after spinal cord injury.