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  4. Does cardiometabolic risk profile differ among individuals with traumatic and non-traumatic spinal cord injury (SCI): the evidence from the multicenter SCI cohort in Switzerland (SwiSCI)

Does cardiometabolic risk profile differ among individuals with traumatic and non-traumatic spinal cord injury (SCI): the evidence from the multicenter SCI cohort in Switzerland (SwiSCI)

Spinal Cord, 2024 · DOI: https://doi.org/10.1038/s41393-024-00996-5 · Published: May 15, 2024

Spinal Cord InjuryCardiovascular ScienceRehabilitation

Simple Explanation

This study explores the cardiometabolic risk profiles of individuals with traumatic (TSCI) and non-traumatic spinal cord injuries (NTSCI) during their initial rehabilitation. The study found that individuals with NTSCI had a higher prevalence of hypertension, diabetes, and obesity at the start of rehabilitation compared to those with TSCI. Both groups showed improvements in some cardiometabolic risk factors, such as cholesterol and glucose levels, during the rehabilitation period.

Study Duration
4.4 months
Participants
530 individuals with SCI (64% with TSCI and 36% NTSCI)
Evidence Level
Longitudinal study

Key Findings

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    At admission, individuals with NTSCI had a higher prevalence of hypertension, diabetes and obesity, and a significantly higher Framingham Risk Score (FRS).
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    Overall, there was an increase in total cholesterol, HDL-C and HDL/total cholesterol ratio, and a decrease in fasting glucose over the rehabilitation period.
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    There was a greater increase in mean HDL concentration in NTSCI as compared to TSCI.

Research Summary

This study compared cardiometabolic risk profiles between individuals with traumatic (TSCI) and non-traumatic (NTSCI) spinal cord injuries during initial rehabilitation. NTSCI patients presented with a more disadvantageous risk profile at admission, but both groups experienced similar longitudinal changes in cardiovascular risk factors during rehabilitation. The study highlights the need for strategies to decrease the burden of cardiometabolic disease in the early phase of SCI rehabilitation, especially for NTSCI patients.

Practical Implications

Early Screening

Routine CVD screening should be implemented during initial rehabilitation stay, especially for NTSCI patients.

Medication Management

Future studies should explore the patterns and clinical significance of opioid prescriptions on metabolic changes and rehabilitation outcomes.

Preventive Strategies

The potential of early preventable strategies (e.g., CMD prophylactic medication use, or lifestyle modifications) to improve metabolic health among those with NTSCI should be explored.

Study Limitations

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