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  4. Cough following low thoracic hemisection in the cat

Cough following low thoracic hemisection in the cat

Exp Neurol, 2010 · DOI: 10.1016/j.expneurol.2009.12.015 · Published: March 1, 2010

Spinal Cord InjuryPhysiologyNeuroplasticity

Simple Explanation

This study investigates how the cough reflex recovers in cats after a spinal cord injury in the lower thoracic region. Researchers examined the activity of abdominal muscles and pressure changes during coughing before and after the injury. The study found that despite the spinal cord injury, the cats were still able to cough effectively, and their abdominal muscles showed activity similar to that before the injury. This suggests that the cough motor system can compensate for the damage through some form of recovery or preserved function. The researchers propose that this recovery may be due to the spinal cord's ability to reorganize itself, using alternative pathways to control the muscles involved in coughing. Locomotor training might have also played a role.

Study Duration
21 weeks
Participants
6 adult, spayed female cats
Evidence Level
Not specified

Key Findings

  • 1
    Expiratory motor drive to abdominal muscles is not significantly impaired during cough in cats that are chronically hemisected in the lower thoracic spinal cord.
  • 2
    The mechanical features of the cough reflex as determined from esophageal pressure measurements are similarly resilient.
  • 3
    No significant change in the average Pes was seen across time points.

Research Summary

This study assessed the chronic effects of low thoracic hemisection on the cough reflex in cats. The major finding is that expiratory motor drive to abdominal muscles is not significantly impaired during cough. The mechanical features of the cough reflex, measured by esophageal pressure, also remained resilient after the injury. This suggests a capacity for endogenous recovery or preservation of function within the cough motor system. Potential mechanisms underlying this resilience include the use of alternative neural pathways within the spinal cord and the influence of locomotor training on muscle activity and neuroplasticity.

Practical Implications

Rehabilitation Strategies

Locomotor training may enhance cough function in SCI patients.

Neuroplasticity Mechanisms

Further research into spinal cord reorganization after injury.

Early Intervention

Assessing cough function in early stages of SCI is important.

Study Limitations

  • 1
    Repeated data collection across time in which EMG electrodes are removed and replaced.
  • 2
    Placement of the electrodes likely varied within a region of ~1cm, and therefore different motor unit populations were likely sampled at different post-SCI time points.
  • 3
    The effects of locomotor training on cough specifically have not been tested.

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