Comparison of the efficacy and safety of sacral root magnetic stimulation with transcutaneous posterior tibial nerve stimulation in the treatment of neurogenic detrusor overactivity: an exploratory randomized controlled trial

Transl Androl Urol, 2022 · DOI: 10.21037/tau-22-249 · Published: June 1, 2022

Simple Explanation

This study compares two non-invasive stimulation techniques, repetitive sacral root magnetic stimulation (rSMS) and transcutaneous posterior tibial nerve stimulation (TTNS), for treating neurogenic detrusor overactivity (NDO) in patients with spinal cord injury. Both rSMS and TTNS have shown promise in treating lower urinary tract dysfunction, but it's unclear which is more effective and safer for NDO. The study found that rSMS may be more effective than TTNS in improving bladder capacity and voiding efficiency in patients with NDO, without causing any observed side effects.

Study Duration

12 Months

Participants

50 patients with NDO secondary to suprasacral spinal cord injury (SCI)

Evidence Level

Level 1, Randomized Controlled Trial

Key Findings

1
rSMS showed a statistically greater increase in maximum cystometric capacity (ΔMCC) compared to TTNS.
2
rSMS demonstrated a statistically significant improvement in bladder voiding efficiency (ΔBVE) compared to TTNS.
3
No significant differences were found in other urodynamic parameters (Δ1st IDCV, ΔPdetmax, ΔBC, and ΔPVR) between the two groups.

Research Summary

This study compared the efficacy and safety of rSMS and TTNS for treating NDO in patients with suprasacral SCI. The results indicated that rSMS may be more effective than TTNS in improving bladder capacity and voiding efficiency. Both rSMS and TTNS were well-tolerated, with no adverse reactions observed during the treatment period.

Practical Implications

Clinical Practice

rSMS could be considered as a more effective alternative to TTNS for improving urodynamic parameters in NDO patients.

Further Research

Further research is warranted to investigate the clinical symptom improvement with rSMS and TTNS in NDO patients.

Treatment Strategies

The study supports the use of neuromodulation techniques like rSMS and TTNS as conservative treatment options for NDO.

Study Limitations

1
The study primarily focused on urodynamic differences and did not extensively assess the improvement of NDO clinical symptoms.
2
The sample size was relatively small, which may limit the generalizability of the findings.
3
The study population was limited to patients with NDO secondary to suprasacral SCI, which may not be representative of all NDO patients.

Your Feedback

Was this summary helpful?

Back to Urology