Circ_0006640 transferred by bone marrow‑mesenchymal stem cell‑exosomes suppresses lipopolysaccharide‑induced apoptotic, inflammatory and oxidative injury in spinal cord injury

This study investigates the role of circ_0006640, a circular RNA, in spinal cord injury (SCI). It explores how circ_0006640, transferred via mesenchymal stem cell-derived exosomes, affects cell death, inflammation, and oxidative stress in SCI models. The research uses SCI animal models and lipopolysaccharide (LPS)-stimulated microglial cells to mimic SCI conditions. It examines gene and protein levels, cell characteristics, and oxidative stress to understand the impact of circ_0006640. The findings suggest that circ_0006640, when transferred by exosomes, can protect microglial cells from LPS-induced injury by targeting the miR-382-5p/IGF-1 axis, offering a potential therapeutic approach for SCI recovery.

• 1
  Circ_0006640 expression is decreased in SCI mice and LPS-induced microglial cells, suggesting its involvement in SCI pathology.
• 2
  Overexpression of circ_0006640 protects microglial cells from LPS-induced apoptosis, inflammation, and oxidative stress, indicating its protective role.
• 3
  Circ_0006640, packaged into MSC-exosomes, can be transferred to microglial cells and exert protective effects via the miR-382-5p/IGF-1 axis.