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  4. Chronic kidney disease, preoperative use of antispasmodics and lower resected prostate volume ratios are risk factors for postoperative use of adrenergic Alpha-blockers and antispasmodics

Chronic kidney disease, preoperative use of antispasmodics and lower resected prostate volume ratios are risk factors for postoperative use of adrenergic Alpha-blockers and antispasmodics

PLoS ONE, 2023 · DOI: https://doi.org/10.1371/journal.pone.0282745 · Published: March 9, 2023

Urology

Simple Explanation

This study investigates factors that lead to the need for medications (alpha-blockers and antispasmodics) after prostate surgery for benign prostatic hyperplasia (BPH). It examines patient data to identify characteristics that might predict the need for these medications post-surgery. The study found that patients with chronic kidney disease (CKD) were more likely to require alpha-blockers after surgery. Additionally, those who used antispasmodics before surgery and had a lower ratio of prostate tissue removed during surgery were more prone to needing antispasmodics afterward. These findings can help doctors better understand which patients might need continued medication after prostate surgery and adjust treatment plans accordingly.

Study Duration
5.3 years
Participants
250 patients receiving prostate surgery for BPH
Evidence Level
Retrospective clinical data analysis

Key Findings

  • 1
    Chronic kidney disease (CKD) is associated with increased postoperative usage of adrenergic alpha-blockers.
  • 2
    Preoperative usage of antispasmodics is a risk factor for postoperative antispasmodic usage.
  • 3
    A lower resected prostate volume ratio is a protective factor against postoperative antispasmodic medications.

Research Summary

The study aimed to identify BPH patients who require adrenergic alpha-blockers and antispasmodics for at least three months after receiving surgery using preoperative and perioperative data. The results showed that BPH patients with underlying CKD were more likely to require alpha-blockers after surgery, and patients who required antispasmodics before surgery and who received lower prostate volume resection ratio were more liable to antispasmodics after prostate surgery. The study concludes that preoperative and perioperative factors can help predict the need for postoperative medications in BPH patients undergoing prostate surgery.

Practical Implications

Patient Counseling

Inform patients with CKD about the increased likelihood of needing alpha-blockers post-surgery.

Surgical Planning

Consider the resected prostate volume ratio to minimize the need for postoperative antispasmodics.

Postoperative Management

Closely monitor patients with a history of antispasmodic use for potential continued need after surgery.

Study Limitations

  • 1
    Retrospective study design limiting data availability (e.g., IPSS scores).
  • 2
    Lack of severity and duration data for comorbidities.
  • 3
    Potential patient preference bias regarding medication use.

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