Characteristics and stability of sensorimotor activity driven by isolated‑muscle group activation in a human with tetraplegia

This study looks at how the brain represents movements, specifically wrist muscle contractions, in a person with tetraplegia who has microelectrode arrays (MEAs) implanted in their brain. The researchers mapped the areas of the brain that control wrist movements and how stable these areas are over time. They found that while activity at individual recording sites can change, the overall pattern of brain activity related to wrist movement remains relatively stable.

• 1
  Channel-level firing strength stability decreased with increased passage of time between data comparisons.
• 2
  Within-channel stability was higher for contralateral than ipsilateral channels for both firing strength and dynamics, and higher for sensory channels than motor in firing dynamics only.
• 3
  At the ensemble level, no stability differences were observed in manifold trajectories, either over time or by brain area.