Body Weight‑Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD‑65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury

Spasticity, a common issue after spinal cord injury, is linked to reduced production of GABA and KCC2 in the spinal cord. This study investigates if treadmill training can boost GAD-65/67 and KCC2 expression via TrkB signaling. The research shows that exercise can lower motoneuronal excitability and increase GAD-65, GAD-67, and KCC2 production.

• 1
  SCI causes hind limb spasticity, increases the Hmax/Mmax ratio, and reduces the RDD value.
• 2
  Exercise training increases the level of expression for BDNF, TrkB, CREB, p-CREB, GAD-56, GAD-67, and KCC2.
• 3
  Blocking TrkB signaling reduces the expression levels of CREB, p-CREB, GAD-56, GAD-67, and KCC2 in SCI-TT/TrkB-IgG group.