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  4. Baseline predictors of in‑hospital mortality after acute traumatic spinal cord injury: data from a level I trauma center

Baseline predictors of in‑hospital mortality after acute traumatic spinal cord injury: data from a level I trauma center

Scientific Reports, 2022 · DOI: https://doi.org/10.1038/s41598-022-15469-z · Published: July 14, 2022

Spinal Cord InjuryTraumaPublic Health

Simple Explanation

This study looked at factors that predict whether someone with a traumatic spinal cord injury (tSCI) would die while in the hospital. They found that having pre-existing kidney or liver disease increased the risk of death. The study also considered end-of-life decisions, which were made in a large percentage of the deaths. The researchers emphasize the importance of carefully considering medication choices for tSCI patients, especially those with kidney or liver problems. The increasing number of elderly patients with tSCI often have other health issues that contribute to higher mortality rates. These findings can help doctors identify high-risk patients early and improve their care.

Study Duration
2011 to 2017
Participants
321 patients admitted after acute tSCI
Evidence Level
Not specified

Key Findings

  • 1
    Pre-existing kidney disease, liver disease, and metastatic tumor were identified as the most relevant predictors associated with in-hospital mortality after tSCI.
  • 2
    Age was also a predictor; patients over 78 years old had a higher risk of in-hospital mortality.
  • 3
    End-of-life decisions were made in 70% of the in-hospital deaths, highlighting the importance of considering these decisions in mortality studies.

Research Summary

This retrospective cohort study analyzed data from 321 patients treated for acute tSCI between 2011 and 2017 to identify risk factors for in-hospital mortality. The study found that pre-existing kidney or liver disease were significant predictors of in-hospital mortality, and a high percentage of deaths involved end-of-life decisions. The findings highlight the need for careful pharmaceutical treatment decisions and appropriate reporting of end-of-life decisions in upcoming studies on in-hospital mortality after tSCI.

Practical Implications

Early Identification of High-Risk Patients

Identifying patients with pre-existing kidney or liver disease allows for early recognition of those at higher risk of in-hospital mortality.

Optimized Pharmaceutical Treatment

Understanding the impact of kidney and liver impairment on drug metabolism can improve pharmaceutical treatment regimens for tSCI patients.

Improved Reporting of End-of-Life Decisions

Appropriate reporting of end-of-life decisions in future studies will provide a more complete picture of in-hospital mortality after tSCI.

Study Limitations

  • 1
    Monocentric data collection limits generalizability.
  • 2
    Low number of deceased patients requires cautious interpretation of odds ratios.
  • 3
    Exclusion of deaths at the injury site, during transport, or after discharge.

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