Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. Associations of RBC counts and incidence of DVT in patients with spinal cord injury: a five year observational retrospective study

Associations of RBC counts and incidence of DVT in patients with spinal cord injury: a five year observational retrospective study

Journal of Orthopaedic Surgery and Research, 2024 · DOI: https://doi.org/10.1186/s13018-024-04838-1 · Published: June 5, 2024

Spinal Cord InjuryCardiovascular Science

Simple Explanation

This study explores the relationship between red blood cell (RBC) counts and the occurrence of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI). It aims to determine if RBC counts can be used as a predictor or risk factor for DVT in this specific population. The study found that RBC counts below a certain level (4.56 × 10^12/L) may protect against DVT, while counts above this level could increase the risk. This suggests that maintaining RBC counts within a specific range could be important for preventing DVT in SCI patients. These findings could help in creating better DVT prevention plans for SCI patients. By carefully watching and managing RBC counts, doctors might be able to lower the chances of DVT in these individuals.

Study Duration
5 Years
Participants
319 patients with spinal cord injury
Evidence Level
Not specified

Key Findings

  • 1
    A 1.00 × 10^12/L increase in RBC counts correlated with a 45% decrease in DVT incidence, but only up to a certain threshold.
  • 2
    The relationship between RBC counts and DVT incidence is 'U' shaped, suggesting that both low and high RBC counts can increase DVT risk.
  • 3
    The threshold (fold point) was identified at 4.56 × 10^12/L, below which increasing RBC counts reduced DVT risk, and above which increasing RBC counts dramatically increased DVT risk.

Research Summary

This retrospective study analyzed data from 319 patients with spinal cord injury (SCI) to investigate the association between red blood cell (RBC) counts and the incidence of deep vein thrombosis (DVT). The results indicated a 'U' shaped relationship, with RBC counts below 4.56 × 10^12/L acting as a protective factor and counts above this threshold posing a risk for DVT. The study suggests that monitoring and managing RBC counts in SCI patients could inform the development of targeted DVT prevention strategies.

Practical Implications

Clinical Monitoring

Regular monitoring of RBC counts in SCI patients can help identify those at higher risk of developing DVT.

Preventive Strategies

The findings can inform the development of targeted DVT prevention strategies, particularly focusing on maintaining RBC counts within the optimal range.

Further Research

Future longitudinal studies are needed to confirm these findings and understand the long-term effects of RBC counts on DVT incidence.

Study Limitations

  • 1
    The observational retrospective nature of the study limits the ability to establish causality.
  • 2
    Patients who received red blood cell transfusions were excluded, potentially affecting the generalizability of the results.
  • 3
    The study lacks longitudinal data to assess the long-term effects of RBC counts on DVT incidence.

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury