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  4. A rare case of extensive neurogenic heterotopic ossification: a case report

A rare case of extensive neurogenic heterotopic ossification: a case report

BMC Musculoskeletal Disorders, 2024 · DOI: https://doi.org/10.1186/s12891-024-07369-2 · Published: April 16, 2024

NeurologyOrthopedicsResearch Methodology & Design

Simple Explanation

Neurogenic Heterotopic ossification (NHO) is a potential sequalae and a detrimental complication following neurological insult. It is characterized by formation of localized gradually progressive, peri-articular lamellar bone formation in extra-skeletal tissues. The patient had a crippled posture, significant pain and impaired range of motion hampering movement of all four limbs which prevented him from lying down supine, sitting, walking and performing activities of daily living. After three surgeries, the patient achieved wheelchair mobilization and upright posture with the assistance of calipers.

Study Duration
2 years follow up
Participants
1 male patient, 33-year-old
Evidence Level
Level 4, Case Report

Key Findings

  • 1
    We present a case of a 33-year-old bed ridden male, diagnosed with NHO involving all 4 limbs (bilateral hip, right knee, right shoulder, left elbow).
  • 2
    After three surgeries, the patient achieved wheelchair mobilization and upright posture with the assistance of calipers.
  • 3
    Clinical image at 2 years follow up where patient is able to sit independently and is able to carry out activities of daily living.

Research Summary

Neurogenic Heterotopic ossification (NHO) is a potential sequalae and a detrimental complication following neurological insult. It is characterized by formation of localized gradually progressive, peri-articular lamellar bone formation in extra-skeletal tissues. We present a case of a 33-year-old bed ridden male, diagnosed with NHO involving all 4 limbs (bilateral hip, right knee, right shoulder, left elbow). After three surgeries, the patient achieved wheelchair mobilization and upright posture with the assistance of calipers.

Practical Implications

Multidisciplinary Approach

Management of NHO requires orthopaedic surgeons, neurologists & rehabilitation specialists.

Factors Influencing Prognosis

Prognosis of NHO depends on the extent of ossification, underlying neurological condition & patient's overall health.

Surgical Considerations

Staged operations with meticulous dissection were crucial due to the major nature of surgeries to avoid increased morbidity.

Study Limitations

  • 1
    Severity of spasticity affected patient's prognosis.
  • 2
    The case report focuses on a single patient, limiting generalizability.
  • 3
    Long-term outcomes beyond the 2-year follow-up are not documented.

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