A neuro-cardiac self-regulation therapy to improve autonomic and neural function after SCI: a randomized controlled trial protocol

BMC Neurology, 2021 · DOI: https://doi.org/10.1186/s12883-021-02355-w · Published: August 13, 2021

Spinal Cord Injury Cardiovascular Science Neurology

Simple Explanation

This study aims to evaluate a neuro-cardiac self-regulation therapy (HRV-F) for improving autonomic and neural function in adults with Spinal Cord Injury (SCI). The therapy involves computer-based feedback of heart rate variability and controlled breathing exercises, delivered weekly over 10 weeks. The study will assess the impact of HRV-F on autonomic nervous system function, cerebral blood circulation, cognitive capacity, psychological status, and quality of life.

Study Duration

12 Months

Participants

120 adults with chronic SCI

Evidence Level

Level 1, Randomized Controlled Trial

Key Findings

1
The primary objective is to determine if HRV-F improves autonomic regulation and brain/neural activity in adults with SCI.
2
Secondary objectives include assessing whether HRV-F leads to improvements in mental health, cognitive capacity, vitality/fatigue, pain, and sleep in SCI patients.
3
The study will also develop a strategic plan for translating findings to individuals with SCI living in the community with disability and at-risk from secondary conditions.

Research Summary

This research protocol outlines a randomized controlled trial to investigate the effectiveness of neuro-cardiac self-regulation therapy (HRV-F) for improving autonomic and neural function in adults with SCI. The study will involve 120 participants with chronic SCI, randomly assigned to either the HRV-F intervention group or a control group receiving usual community care. Comprehensive assessments will be conducted at baseline, post-treatment, and at 6 and 12-month follow-ups to evaluate the impact of HRV-F on autonomic function, brain activity, and various secondary health conditions.

Practical Implications

Clinical Practice

If HRV-F is effective, it could be integrated into rehabilitation programs to improve autonomic function and related health outcomes in SCI patients.

Research

The study may improve understanding of the physiological mechanisms underlying brain-autonomic dysfunction and the influence of neuroplasticity.

Community Translation

Findings can be used to develop guidelines for implementing HRV-F in community settings, improving accessibility and long-term health management for individuals with SCI.

Study Limitations

1
The study involves a single-blind design, as it is not possible to blind participants and intervention providers to the HRV-F versus control conditions.
2
Reliance on self-report measures for some secondary outcomes may introduce potential biases.
3
Generalizability may be limited to English-speaking adults with SCI living in New South Wales, Australia.

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