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  4. Treadmill Training with HAL Exoskeleton—A Novel Approach for Symptomatic Therapy in Patients with Limb-Girdle Muscular Dystrophy—Preliminary Study

Treadmill Training with HAL Exoskeleton—A Novel Approach for Symptomatic Therapy in Patients with Limb-Girdle Muscular Dystrophy—Preliminary Study

Frontiers in Neuroscience, 2017 · DOI: 10.3389/fnins.2017.00449 · Published: August 8, 2017

NeurologyNeurorehabilitation

Simple Explanation

Exoskeletons, like the HAL® (hybrid assistive limb), have been developed to help patients with walking difficulties due to neurological disorders. This study explores using HAL®-supported treadmill therapy for patients with limb-girdle muscular dystrophy (LGMD). Three LGMD patients underwent 8 weeks of treadmill training with the HAL® exoskeleton, three times per week. Researchers assessed walking function before, immediately after, and 6 weeks after the training. The study found that the HAL® treadmill training was safe for LGMD patients and enabled intensive, repetitive locomotor training. All patients experienced some benefits from this method.

Study Duration
8 weeks
Participants
3 LGMD patients
Evidence Level
Not specified

Key Findings

  • 1
    All patients completed the 8-week therapy without any adverse reactions and reported improvements in their endurance.
  • 2
    Improvements in walking function, as measured by the 10-meter walk test (10MWT), 6-minute walk test (6MWT), and timed-up-and-go test (TUG), were observed after the 8-week training period.
  • 3
    The improvements in 10MWT and TUG tests persisted even after 6 weeks of follow-up, suggesting lasting effects of the training.

Research Summary

This study investigated the safety and effects of HAL®-supported treadmill therapy on walking function in patients with limb-girdle muscular dystrophy (LGMD). Three LGMD patients underwent an 8-week training program with the HAL® exoskeleton, and their walking function was assessed before, after, and 6 weeks post-training. The results showed that HAL® treadmill training is safe and effective for LGMD patients, leading to improvements in walking function and endurance, with some effects persisting after 6 weeks.

Practical Implications

Feasibility and Safety

The study demonstrates that HAL®-assisted treadmill training is feasible and safe for ambulatory patients with LGMD, opening possibilities for its use in clinical settings.

Potential for Improved Walking Function

The results suggest that HAL® training can improve walking function in LGMD patients, particularly in walking speed and functional mobility.

Foundation for Further Research

The study provides a basis for larger, controlled studies to further investigate the effects of HAL® training in different types of LGMD and other myopathies.

Study Limitations

  • 1
    Small sample size of only three LGMD patients
  • 2
    Lack of a control group
  • 3
    Specific measurements for endurance capacity and serum CK levels were not collected

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