Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function

The research investigates whether thin myelin sheaths, a sign of remyelination, persist over long periods and continue to support nerve function. The study uses two animal models: dogs with a genetic myelin disorder and cats with demyelination caused by irradiated food. In dogs with a genetic disorder causing delayed myelination, thin myelin sheaths were observed to persist for 13 years without harming the axons. Similarly, in cats with demyelination, thin remyelinated axons persisted for over two years. The findings suggest that thin myelin sheaths can endure for extended periods and maintain nerve function, which is crucial for developing effective strategies to promote myelin repair in conditions like multiple sclerosis.

• 1
  Thin myelin sheaths persist for up to 13 years in dogs with a genetic myelin disorder without causing axon degeneration.
• 2
  Thin remyelinated axons persist for over 2 years in cats with demyelination induced by irradiated food.
• 3
  The study confirms the longevity of thin myelin sheaths and their importance in maintaining long-term health and function in the central nervous system.