The mechanism of astragaloside IV promoting sciatic nerve regeneration

This study investigates the potential of astragaloside IV, a component of traditional Chinese medicine, to aid in the repair of injured sciatic nerves in mice. Mice with denervated sciatic nerves were treated with different doses of astragaloside IV for eight days, and the expression of growth-associated protein-43 was examined. The study found that astragaloside IV can improve sciatic nerve regeneration and functional recovery in mice, possibly by increasing the expression of growth-associated protein-43.

• 1
  Astragaloside IV accelerates nerve myelin sheath growth in mice with sciatic nerve injury and increases the diameter and number of myelinated nerve fibers.
• 2
  Astragaloside IV elevates and accelerates peripheral nerve regeneration and functional reconstruction by upregulating growth-associated protein-43 expression.
• 3
  Growth-associated protein-43 expression was upregulated in mouse spinal cord segments L4–6 after intervention with 10, 5, 2.5 mg/kg astragaloside IV per day in a dose-dependent manner.