Cell Reports Medicine, 2024 · DOI: https://doi.org/10.1016/j.xcrm.2024.101515 · Published: May 21, 2024
This study examines how maternal SARS-CoV-2 infection impacts the development of fetal germ cells (FGCs), which are crucial for reproduction. Researchers analyzed the transcriptome and DNA methylome of FGCs from pregnancies affected by COVID-19. The study found that maternal COVID-19 infection during early pregnancy has limited effects on FGC development. However, there's a trend toward an "in advance" or precocious development in FGCs after maternal infection. The gonadal microenvironment, which includes cells surrounding the FGCs, activates extensive immune responses to protect FGCs from maternal infection. This helps maintain the integrity of FGC development and ensures the transfer of genetic information to the next generation.
The study serves as potential clinical guidance for future pandemics, providing insights into the impacts of maternal SARS-CoV-2 infection on fetal germline development.
The research provides insights into individuals of reproductive age, enhancing understanding of epigenetic and transcriptional programs of the human germline following maternal perturbations.
The findings indicate efficient transfer of immune memory to the next-generation individuals, explaining human-specific immune innovation from an evolutionary point of view.