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  4. The Antimicrobial and Healing Effect of Scrophularia striata Boiss Hydroalcoholic Extract on First- and Second-Grade Pressure Wounds in Patients with Brain and Spinal Cord Injury: A Randomized Clinical Trial

The Antimicrobial and Healing Effect of Scrophularia striata Boiss Hydroalcoholic Extract on First- and Second-Grade Pressure Wounds in Patients with Brain and Spinal Cord Injury: A Randomized Clinical Trial

Evidence-Based Complementary and Alternative Medicine, 2022 · DOI: https://doi.org/10.1155/2022/8522937 · Published: November 28, 2022

Alternative MedicineDermatology

Simple Explanation

Pressure ulcers are a common problem for patients with brain and spinal cord injuries, leading to pain, infection, and hospitalizations. This study investigated whether a plant extract, Scrophularia striata hydroalcoholic extract (SHE), could help heal these ulcers. The study involved 120 patients with grade 1 and 2 pressure ulcers, divided into four groups. One group received SHE and phenytoin, another received only SHE, a control group received phenytoin, and a placebo group received eucerin and phenytoin. The treatments were applied twice daily. The results showed that the group treated only with SHE had the best outcomes, with complete wound healing in all patients by the 10th day. This suggests that SHE has potential as a treatment for pressure ulcers in patients with brain and spinal cord injuries.

Study Duration
From December 2019 to October 2020
Participants
120 patients with cerebral-spinal cord lesions
Evidence Level
Level 1: Randomized Controlled Trial

Key Findings

  • 1
    Complete wound healing by the 10th day of the intervention occurred in 63% of patients in experimental 1 (SHE + phenytoin), 100% in experimental 2 (SHE + SHE), and 27% in the control group (phenytoin + phenytoin).
  • 2
    The placebo group had no complete wound healing until the 10th day of the intervention.
  • 3
    The time of complete ulcer healing patients in experiment group 2 was less than in group 1 and the control group.

Research Summary

This study investigated the effects of Scrophularia striata hydroalcoholic extract (SHE) on healing pressure ulcers in patients with brain and spinal cord injuries. The study found that topical application of SHE twice a day led to higher potency to heal wounds and reduced the duration of complete wound healing compared to other groups. The study concludes that SHE has good potential to accelerate the healing of first- and second-degree pressure wounds in patients with brain-spinal cord injuries.

Practical Implications

New Treatment Option

Scrophularia striata extract can be considered as a novel treatment option for pressure ulcers.

Reduced Hospitalization

Using Scrophularia striata could potentially reduce the period of hospitalization for patients with pressure ulcers.

Improved Medical Services

The use of Scrophularia striata may improve the quality of medical services and care for patients with pressure ulcers.

Study Limitations

  • 1
    Limited sample size due to the COVID-19 pandemic.
  • 2
    Several patients were discharged from the hospital before the study time.
  • 3
    The study focused on first- and second-grade pressure ulcers only.

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