Substance P and calcitonin gene-related peptide expression in dorsal root ganglia in sciatic nerve injury rats

This study investigates the role of substance P and calcitonin gene-related peptide in the repair of sciatic nerve injury in rats. A sciatic nerve defect model was created in rats, and the expression of these neuropeptides in the dorsal root ganglia was examined at different time points. The findings suggest that these neuropeptides play a significant role in the early stages of nerve repair. The researchers found that the expression of substance P and calcitonin gene-related peptide increased significantly in the dorsal root ganglion of rats with sciatic nerve injury. This increase peaked at 7 days, declined at 14 days, and returned to normal levels by 28 days post-injury, suggesting their involvement in early nerve regeneration processes. These neuropeptides are known to transmit pain signals and may also contribute to nerve repair following injury. The study's findings suggest that they could potentially serve as indicators for evaluating early peripheral nerve injury.

• 1
  Substance P and calcitonin gene-related peptide expression in dorsal root ganglia were altered over time in rats with sciatic nerve injury.
• 2
  The expression of substance P and calcitonin gene-related peptide mainly increased in the early stages after sciatic nerve injury.
• 3
  Substance P and calcitonin gene-related peptide are involved in transmitting pain signals and play a role in repair following sciatic nerve injury.