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  4. Strategies to avoid a missed diagnosis of co-occurring concussion in post-acute patients having a spinal cord injury

Strategies to avoid a missed diagnosis of co-occurring concussion in post-acute patients having a spinal cord injury

Neural Regeneration Research, 2015 · DOI: 10.4103/1673-5374.158329 · Published: June 1, 2015

NeurologyRehabilitationBrain Injury

Simple Explanation

A missed diagnosis of a concussion after a spinal cord injury can have negative consequences for patients and skew research results. Clinicians should be aware of the possibility of a missed traumatic brain injury (TBI) diagnosis in patients with spinal cord injuries (SCI). The presence of acute trauma-related life-threatening issues and/or the need for sedation or intubation during acute care hospitalizations of SCI patients may result in a missed diagnosis of mild-moderate severity TBIs. The diagnosis of a concomitant concussion and particularly of a mild-moderate severity TBI, in a SCI patient is important for planning rehabilitation interventions, to maximize functional returns, and for the prevention, anticipation, and early treatment of possible related medical complications.

Study Duration
Not specified
Participants
Post-acute patients having spinal cord injuries
Evidence Level
Level 5, Perspective

Key Findings

  • 1
    The incidence of a dual diagnosis of SCI with a co-occurring TBI may approach 60–74% with certain risk factors such as a motor vehicle collision or a fall.
  • 2
    Mild traumatic brain injury (MTBI), also known as a concussion, occurs most commonly in 64–73% of dual diagnosis cases.
  • 3
    Factors that may lead to a missed diagnosis include the subtle neuropathology of mild TBI, focus on SCI management, failure to collect GCS scores, and symptom overlap.

Research Summary

Research scientists and clinicians should be aware that missed diagnoses of mild-moderate traumatic brain injuries in post-acute patients having spinal cord injuries may approach 60–74% with certain risk factors, potentially causing clinical consequences for patients, and confounding the results of clinical research studies. Factors leading to a missed diagnosis may include acute trauma-related life-threatening issues, sedation/intubation, subtle neuropathology on neuroimaging, failure to collect Glasgow Coma Scale scores or duration of posttraumatic amnesia, or lack of validity of this information, and overlap in neuro-cognitive symptoms with emotional responses to spinal cord injuries. Strategies for avoiding a missed diagnosis of mild-moderate traumatic brain injuries in patients having a spinal cord injuries are highlighted in this perspective.

Practical Implications

Improved Rehabilitation Planning

Accurate diagnosis of concomitant concussion helps in planning rehabilitation interventions and maximizing functional returns.

Enhanced Clinical Research

Avoiding missed TBI diagnoses in SCI patients ensures that clinical research protocol outcomes are not confounded.

Early Treatment of Complications

Early diagnosis helps in the prevention, anticipation, and early treatment of possible related medical complications.

Study Limitations

  • 1
    Subtle neuropathology of mild TBI may not be detected by CT or conventional MRI.
  • 2
    Overlap in symptoms between mild-moderate TBIs and emotional responses to SCI.
  • 3
    Intubation, sedation, seizures, and/or alcohol or other drug/substance intoxication may confound the initial assessment of GCS scores.

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