PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood

This study aimed to identify key biomarkers related to immune infiltration and osteoclast differentiation in ankylosing spondylitis (AS) using bioinformatic methods. The researchers used gene expression data from the Gene Expression Omnibus database and performed various bioinformatics analyses to identify differentially expressed genes and their functions. The study found that dysregulation of PLCG2 and IFNAR1 are key factors in the development of AS through regulating immune infiltration and osteoclast differentiation.

• 1
  125 DEGs were identified, consisting of 36 upregulated and 89 downregulated genes that are involved in the cell cycle and replication processes.
• 2
  Immune infiltration analysis found that naive CD4+ T cells and monocytes may be involved in the process of AS.
• 3
  The mRNA expression levels of PLCG2 in AS were significantly higher than that in the normal person, while IFNAR1 mRNA expression levels were significantly lower.