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  4. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Lancet Neurology, 2019 · DOI: http://dx.doi.org/10.1016/S1474-4422(18)30499-X · Published: May 1, 2019

NeurologyPublic Health

Simple Explanation

This study examines the impact of neurological disorders worldwide from 1990 to 2016. The study looks at deaths and disabilities caused by 15 different categories of neurological disorders. The study finds that neurological disorders are a major cause of disability and death, and their impact is growing as the population ages.

Study Duration
26 Years
Participants
195 countries
Evidence Level
Systematic analysis

Key Findings

  • 1
    Neurological disorders are the leading cause of disability and the second leading cause of death worldwide.
  • 2
    Stroke, migraine, Alzheimer’s disease and other dementias, and meningitis were the four largest contributors of neurological DALYs.
  • 3
    The burden of neurological disorders is increasing globally, particularly in low-income and middle-income countries.

Research Summary

Neurological disorders are a leading cause of death and disability worldwide, with an increasing burden as populations grow and age. Stroke, migraine, Alzheimer’s disease and other dementias, and meningitis contribute most to neurological disability-adjusted life-years (DALYs). Age-standardised DALY rates for neurological disorders were significantly higher in males than in females.

Practical Implications

Increased demand for services

Governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders as populations age.

Need for new knowledge

The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.

Resource allocation

Regular updates on the global, regional, and national burden from neurological disorders allow evidence-based health-care planning and resource allocation for these disorders.

Study Limitations

  • 1
    Measurement bias in diagnosing certain neurological disorders.
  • 2
    Sparse data in many countries, relying on predictive covariates.
  • 3
    Incomplete assessment of deaths from nature of injury.

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