Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model

PLoS ONE, 2023 · DOI: https://doi.org/10.1371/journal.pone.0280304 · Published: January 13, 2023

Simple Explanation

This research investigates the potential of hair-follicle-associated pluripotent (HAP) stem cells to repair intracerebral hemorrhage (ICH) and reduce neuroinflammation. The study found that HAP stem cells can differentiate into various brain cells and suppress inflammation in a mouse model of ICH. The authors suggest that HAP stem cells offer advantages over other stem cell types due to their non-tumorigenic nature and autologous potential.

Study Duration

42 days post-ICH

Participants

C57BL/6J mice and BALB/cAJcl-nu/nu female mice (nude mice)

Evidence Level

Not specified

Key Findings

1
HAP stem cells differentiated into neurons, astrocytes, oligodendrocytes, and microglia in the ICH site of nude mice after allo transplantation.
2
HAP stem cells suppressed astrocyte and microglia infiltration in the injured brain after autologous transplantation in C57BL/6J mice.
3
HAP-stem-cell implantation improves sensorimotor function and weight gain in C57BL/6J mice with ICH.

Research Summary

This study demonstrates that HAP stem cells can differentiate into neural cells and reduce neuroinflammation in a mouse model of ICH. The implantation of HAP stem cells resulted in improved sensorimotor function and weight gain in mice with ICH. The authors suggest HAP stem cells have future clinical potential for the treatment of ICH due to their unique properties and the positive outcomes observed in the mouse model.

Practical Implications

Therapeutic Potential for ICH

HAP stem cells could be a novel therapeutic approach for treating ICH, a condition with limited effective treatments.

Advantages over Other Stem Cells

HAP stem cells offer benefits like non-tumorigenicity and autologous use, potentially overcoming limitations of iPSCs and ESCs.

Regenerative Medicine Application

This research supports the use of stem cell therapy for neural repair and functional recovery after brain injury.

Study Limitations

1
Study conducted on a mouse model, limiting direct translation to human patients.
2
Further research is needed to understand the long-term effects and safety of HAP stem cell implantation.
3
The precise mechanisms by which HAP stem cells promote functional recovery require further investigation.

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