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  4. Correction to: Profiling age‑related muscle weakness and wasting: neuromuscular junction transmission as a driver of age‑related physical decline

Correction to: Profiling age‑related muscle weakness and wasting: neuromuscular junction transmission as a driver of age‑related physical decline

GeroScience, 2021 · DOI: https://doi.org/10.1007/s11357-021-00464-5 · Published: October 13, 2021

AgingNeurology

Simple Explanation

This article is a correction to a previously published article regarding age-related muscle weakness and wasting. The correction pertains to Figure 1, where the image and legend were published erroneously in the original article. The corrected figure displays data on neuromuscular junction transmission in aged rats, showing deficits compared to younger rats.

Study Duration
Not specified
Participants
Young rats, n=8 (3 females, 5 males) and aged rats, n=8 (3 females, 5 males)
Evidence Level
Animal study

Key Findings

  • 1
    Aged rats show significant deficits in neuromuscular junction transmission.
  • 2
    Repetitive nerve stimulation showed a significant reduction of compound muscle action potential (CMAP) amplitudes in aged rats compared to young rats.
  • 3
    Single fiber electromyography revealed increased variability of transmission (jitter) and increased blocking at the neuromuscular junction in aged rats.

Research Summary

This correction addresses an error in the original publication concerning Figure 1 and its legend. The corrected figure presents data from experiments on aged and young rats, focusing on neuromuscular junction transmission. The findings indicate that aged rats exhibit deficits in neuromuscular junction transmission, potentially contributing to age-related muscle decline.

Practical Implications

Improved Data Interpretation

Ensures accurate understanding of the original study's findings by correcting a key visual element.

Reinforced Focus on NMJ

Highlights the importance of neuromuscular junction transmission in age-related muscle decline.

Future Research Guidance

Provides corrected data for future studies investigating age-related neuromuscular changes.

Study Limitations

  • 1
    Correction of a figure error only
  • 2
    Limited scope to neuromuscular junction transmission
  • 3
    Animal model may not fully translate to human physiology

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