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  4. Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Scientific Reports, 2018 · DOI: 10.1038/s41598-017-18293-y · Published: January 3, 2018

Assistive TechnologyNeurologyRehabilitation

Simple Explanation

After a spinal cord injury (SCI), the body relies more on sensory feedback from the legs to control movement. Therapies often focus on guiding leg movements to enhance this feedback. This study investigates the impact of trunk posture, which is often overlooked, on restoring movement after SCI. Researchers developed a robotic system to control trunk posture in rats with severe SCI. They found that adjusting the trunk's position improved balance and symmetry in leg movements. This suggests that trunk control is important for optimizing rehabilitation. The study also used computer simulations to understand how trunk posture affects sensory feedback from leg muscles. They found that proper trunk alignment helps balance the signals from muscles that flex and extend the legs, leading to better stepping quality.

Study Duration
Not specified
Participants
5 rats with severe spinal cord injury
Evidence Level
Not specified

Key Findings

  • 1
    Real-time control of trunk posture re-established dynamic balance amongst bilateral proprioceptive feedback circuits, restoring symmetry, loading, and stepping consistency in rats with severe SCI.
  • 2
    The robotic system revealed relationships between trunk orientation and the modulation of bilateral leg kinematics and muscle activity.
  • 3
    Computer simulations indicated that trunk orientation modulates the flow of information in muscle spindle feedback circuits, impacting locomotor performance.

Research Summary

This study investigates the role of trunk posture in improving locomotion after spinal cord injury (SCI) using a robotic postural interface in rats. The robotic system and computer simulations revealed that trunk posture significantly affects leg movements and proprioceptive feedback, leading to improved gait symmetry and stepping quality. The closed-loop control strategies that regulated trunk posture and sway in real-time improved locomotor performance, suggesting potential for clinical translation in human gait rehabilitation.

Practical Implications

Clinical Gait Rehabilitation

The study suggests that incorporating trunk postural control into gait rehabilitation protocols for humans with SCI could improve outcomes.

Assistive Device Design

The findings can inform the development of assistive devices that regulate trunk posture in real-time to enhance locomotor performance.

Understanding Proprioceptive Feedback

The research highlights the importance of proprioceptive feedback circuits in locomotor recovery and suggests new avenues for therapeutic intervention.

Study Limitations

  • 1
    The study was conducted on rats, and the results may not directly translate to humans.
  • 2
    The robotic interface was limited to mediolateral trunk movements, neglecting other potentially important degrees of freedom.
  • 3
    The computer model focused on muscle spindle feedback circuits, potentially overlooking other sensory feedback mechanisms.

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