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  4. Botulinum toxin type A for the treatment of muscle contractures secondary to acute spinal cord injury in a young cat

Botulinum toxin type A for the treatment of muscle contractures secondary to acute spinal cord injury in a young cat

Journal of Feline Medicine and Surgery Open Reports, 2020 · DOI: 10.1177/2055116920922648 · Published: April 2, 2020

NeurologyVeterinary Medicine

Simple Explanation

Muscle contractures, or the shortening of muscle tissue, can occur in pets, often after an injury. This can lead to pain and disability. Traditional treatments can be risky, so there's a need for safer options. Botulinum toxin type A (BTX-A) is a neurotoxin that can prevent muscle contraction. It's used in human medicine to treat muscle stiffness. This report describes its successful use in a cat with muscle contractures after a spinal cord injury. A young cat with spinal cord injury developed muscle contractures. After injecting BTX-A into the affected muscles, the contractures resolved, and the cat regained mobility with the help of a splint and physiotherapy. This suggests BTX-A can be a safe and effective treatment option.

Study Duration
6 months follow up
Participants
A 4-month-old male entire domestic shorthair cat
Evidence Level
Case Report

Key Findings

  • 1
    Intramuscular BTX-A injection was effective in treating acquired muscle contractures in a cat secondary to spinal cord injury.
  • 2
    The cat's carpal hyperflexion resolved 24 hours after BTX-A injection, indicating a rapid response to the treatment.
  • 3
    At 6 months post-treatment, the cat was pain-free, able to ambulate with normal paw placement, and only required a splint after prolonged exercise, demonstrating a sustained improvement in quality of life.

Research Summary

This case report describes the successful use of intramuscular botulinum toxin type A (BTX-A) to treat severe muscle contractures in a 4-month-old cat following a spinal cord injury. The cat developed progressive discomfort and hyperflexion of the carpus, which was resolved within 24 hours after the injection of BTX-A into the affected muscles. The cat was then managed with a splint and physiotherapy. Six months post-treatment, the cat was pain-free and able to ambulate with only occasional support from a splint, indicating that BTX-A can be an effective and safe treatment for acquired muscle contractures in cats.

Practical Implications

Novel Treatment Option

BTX-A can be considered as a treatment for acquired muscle contractures in cats, especially when alternative treatments are riskier.

Importance of Adjunctive Therapy

The success of BTX-A treatment relies on combining it with physiotherapy and splinting to maintain a pain-free and functional limb.

Further Research Needed

Further investigation into the use of BTX-A for muscle contractures in veterinary medicine is warranted to better understand its efficacy and safety.

Study Limitations

  • 1
    Single case report limits generalizability.
  • 2
    Long-term effects of BTX-A treatment not fully evaluated.
  • 3
    Subjective assessment of pain and mobility by owners.

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