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  4. Bilateral Upper Extremity Tremors in West Nile Encephalitis

Bilateral Upper Extremity Tremors in West Nile Encephalitis

Cureus, 2023 · DOI: 10.7759/cureus.37168 · Published: April 5, 2023

ImmunologyNeurology

Simple Explanation

West Nile encephalitis, a rare complication of West Nile virus (WNv) infection, can present with symptoms mimicking other neurological diseases. This article reports a case of a 60-year-old female who developed bilateral upper extremity tremors with West Nile encephalitis. The patient presented with high fevers and new onset confusion, followed by persistent tremors throughout her hospitalization. Brain imaging showed no abnormalities, but cerebral spinal fluid (CSF) was positive for WNv IgM, confirming the diagnosis. When patients present with movement disorders and confusion, it often suggests brain or spinal cord injury or other neurological illnesses. However, viral etiologies should be considered, especially when fever and elevated white blood cell count are present.

Study Duration
Not specified
Participants
60-year-old female
Evidence Level
Case Report

Key Findings

  • 1
    The 60-year-old female patient developed bilateral upper extremity tremors, high fever, and confusion, leading to a diagnosis of West Nile encephalitis.
  • 2
    CSF analysis revealed pleocytosis and West Nile IgM, confirming the West Nile virus infection as the cause of the encephalitis.
  • 3
    The patient's symptoms included seizures and altered mentation, which are consistent with encephalitis and highlight the neuroinvasive nature of the West Nile virus in this case.

Research Summary

This case report highlights a rare presentation of West Nile neuroinvasive disease, specifically bilateral tremors in the upper extremities. The case reinforces the importance of considering viral encephalitis in the differential diagnosis when patients present with movement disorders accompanied by high fever and leukocytosis. Early recognition of viral origins in such presentations may help prevent inappropriate treatment and diagnostic testing, leading to more effective patient management.

Practical Implications

Diagnostic Awareness

Clinicians should consider West Nile virus infection in patients presenting with tremors, fever, and confusion, especially during outbreaks.

Treatment Strategies

Focus on supportive care, as there is no specific antiviral treatment for West Nile virus, but early diagnosis can prevent unnecessary antibiotic or antiviral use for other conditions.

Rehabilitation Focus

Patients with West Nile encephalitis may benefit from occupational and physical therapy to improve functional status and manage persistent tremors.

Study Limitations

  • 1
    Single case report limits generalizability.
  • 2
    Patient's late presentation may have impacted treatment options.
  • 3
    Lack of long-term follow-up data on patient's recovery.

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