Anti‑ganglioside antibody positive neuromyelitis optica spectrum disorders with peripheral neuropathy: a case report

Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune disorders affecting the central nervous system, particularly the optic nerve and spinal cord. This report describes a patient with NMOSD who also had peripheral nerve damage, undifferentiated connective tissue disease and tested positive for multiple anti-ganglioside antibodies. The patient improved after treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab.

• 1
  The patient met the diagnostic criteria for AQP4-IgG positive NMOSD with undifferentiated connective tissue disease and multiple peripheral neuropathy.
• 2
  The patient was positive for multiple anti-ganglioside antibodies (anti-GD1a IgG antibodies and anti-GD3 IgM antibodies) and anti-sulfatide IgG antibodies in serum and cerebrospinal fluid.
• 3
  After treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab, the patient's condition improved.