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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 491-500 of 12,052 results

Spinal Cord InjuryPharmacologyBiomedical

Dual-phase SilMA hydrogel: a dynamic scaffold for sequential drug release and enhanced spinal cord repair via neural differentiation and immunomodulation

Front. Bioeng. Biotechnol., 2024 • November 21, 2024

This study constructs a Dual-Phase SilMA hydrogel scaffold (DPSH), incorporating PLGA microspheres encapsulating neurotrophin-3 (NT-3) and angiotensin (Ang-(1–7), and neural stem cells. In vitro studi...

KEY FINDING: Ang-(1–7) significantly induced M2 microglia polarization by 1.8-fold (p < 0.0001), effectively reducing inflammation.

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Spinal Cord InjuryAssistive TechnologyRehabilitation

UPPER LIMB MUSCLE STRENGTH AND WHEELCHAIR-RELATED ABILITIES FOLLOWING AN EXOSKELETON-ASSISTED WALKING PROGRAMME IN INDIVIDUALS WITH CHRONIC SPINAL CORD INJURY: AN EXPLORATORY STUDY

Journal of Rehabilitation Medicine, 2024 • November 21, 2024

This study investigated how upper limb muscle, as well as wheelchair propulsion performance and abilities, are affected immediately after the completion of a 16-week exoskeleton-assisted walking progr...

KEY FINDING: Only natural velocity during the 20-m wheelchair propulsion test (i.e., fundamental wheelchair ability) changed following the intervention (p = 0.01, effect size = 0.82, relative variation = +14.5%).

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Spinal Cord InjuryNeurologyPain Management

Neuropathic pain relief and altered brain networks after dorsal root entry zone microcoagulation in patients with spinal cord injury

Brain Communications, 2024 • November 21, 2024

This study investigated the effectiveness of dorsal root entry zone (DREZ) microcoagulation in relieving below-level neuropathic pain in patients with spinal cord injury (SCI). The research involved p...

KEY FINDING: DREZ microcoagulation resulted in short-term (12 days) and long-term (1+ year) pain relief for participants with SCI below-level neuropathic pain, especially when lesioning both cephalad and caudal to the injury.

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Spinal Cord InjuryRegenerative MedicineImmunology

Combination of Adult Mesenchymal Stem Cell Therapy and Immunomodulation with Dimethyl Fumarate Following Spinal Cord Ventral Root Repair

Biology, 2024 • November 20, 2024

This study investigated the efficiency of combining heterologous fibrin biopolymer (HFB) for reimplantation, mesenchymal stem cell (MSC) therapy, and dimethyl fumarate (DMF) administration in treating...

KEY FINDING: The combined therapy resulted in a reduced glial response and a 70% improvement in behavioral motor recovery.

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Spinal Cord InjuryRegenerative Medicine

Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell‑derived spinal cord progenitor cells

Stem Cell Research & Therapy, 2024 • November 20, 2024

This study introduces MRR as a rapid, label-free method for assessing the safety and quality of iPSC-derived SCPCs by measuring intracellular iron levels. The results demonstrate that MRR can effectiv...

KEY FINDING: Intracellular iron levels are significantly different between iPSCs and SCPCs, allowing MRR to distinguish between the two cell types based on T2 values.

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Spinal Cord InjuryGeneticsNeurorehabilitation

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress

Regenerative Therapy, 2025 • November 20, 2024

Spinal cord ischemia/reperfusion (IR) injury (SCII) can cause major autonomic, sensory, and motor damage and loss. The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, ha...

KEY FINDING: Nrf2 and NFATC2 levels were reduced in PC12 cells after OGD/R treatment.

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Spinal Cord InjuryNeurologyGenetics

Acid‑sensing ion channel‑1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2

Cellular & Molecular Biology Letters, 2024 • November 20, 2024

This study investigates the role of ASIC1A in spinal cord injury (SCI). It reveals that ASIC1A activation in neural stem cells (NSCs) prevents their differentiation into oligodendrocytes, hindering my...

KEY FINDING: ASIC1A is upregulated in NSCs following spinal cord injury.

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Spinal Cord InjuryHealthcareRehabilitation

Perspective of the World Rehabilitation Alliance: Global Strategies to Strengthen Spinal Cord Injury Rehabilitation Services in Health Systems

Healthcare, 2024 • November 20, 2024

SCI rehabilitation services are essential to global health and require workforce development, research, national registries, and integration into primary and emergency care. These efforts aim to impro...

KEY FINDING: Workforce and education are critical areas, underscoring the importance of specialized training, certification, and ongoing support to build capacity in SCI rehabilitation services.

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COVID-19PulmonologyNeurology

Spinal Neuromodulation for Respiratory Rehabilitation in Patients with Post-Acute COVID-19 Syndrome

Life, 2024 • November 20, 2024

This study demonstrates that combining scTS with RT offers significant benefits for respiratory rehabilitation in post-COVID-19 patients. The neuromodulatory effects of scTS led to substantial improve...

KEY FINDING: scTS + RT intervention resulted in an average effect size that was twice as large as RT alone.

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Patient ExperienceNeurorehabilitationRehabilitation

A co-design process to develop personalized mobility programming for individuals with mobility impairments

Front. Rehabil. Sci., 2024 • November 20, 2024

This paper describes a co-design process used to develop personalized mobility programming (PMP) for individuals with mobility impairments, using an adaptive intervention design approach and integrate...

KEY FINDING: The co-design process led to the development of four personalized mobility programs: cognitive cardio class, functional strength class, mobility circuit group, and an open gym.

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