Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,841-11,850 of 12,052 results
The Journal of Neuroscience, 2008 • January 16, 2008
The study examines the electrophysiological and molecular changes in reticulospinal (RS) neurons of larval lampreys following spinal cord injury, specifically focusing on the effects of axotomy on fir...
KEY FINDING: Axotomized RS neurons initially display altered firing patterns, including single short bursts or short repetitive bursts, in response to sustained depolarization.
Glia, 2008 • January 15, 2008
This study investigates the role of NG2, a chondroitin sulfate proteoglycan, in tPA-mediated plasmin generation and its implications for spinal cord injury recovery. The findings indicate that NG2 act...
KEY FINDING: NG2 binds to both tPA and plasminogen, accelerating the conversion of plasminogen to plasmin.
PNAS, 2008 • January 15, 2008
This study investigates the role of Nogo-66 receptor (NgR) in motor neuron survival, revealing that peptides derived from the Nogo-66 sequence, Pep4 and NEP1-40, can prevent p75NTR-dependent motor neu...
KEY FINDING: NgR, LINGO-1, and p75NTR mRNAs are expressed in cultures of purified embryonic motor neurons and NSC34 cells, indicating that NgR activation could involve p75NTR in this paradigm.
BMC Neuroscience, 2008 • January 14, 2008
The study investigates the effect of anti-Nogo-A antibody treatment on cell body shrinkage in the motor cortex of monkeys after unilateral cervical cord lesion. The findings indicate that anti-Nogo-A ...
KEY FINDING: Unilateral cervical lesion does not lead to significant neuronal loss of corticospinal (CS) neurons in the contralesional hemisphere.
Brain Res Rev, 2008 • January 1, 2008
This article discusses the capacity of the functionally isolated human spinal cord to generate locomotor patterns with appropriate sensory input, despite the loss of supraspinal control after spinal c...
KEY FINDING: The functionally isolated human spinal cord has the capacity to generate locomotor patterns with appropriate afferent input, demonstrating the importance of sensory feedback.
Brain, 2008 • January 1, 2008
This study evaluated the effectiveness of olfactory bulb-derived OEG implantation and treadmill step training on hindlimb locomotor recovery in adult rats with complete spinal cord transections. The r...
KEY FINDING: OEG transplantation alone significantly increased the number of plantar steps performed at 7 months post-transection, indicating improved hindlimb function.
J Aging Health, 2008 • January 1, 2008
This study investigated age-related differences in pain coping strategies among adults with chronic pain secondary to disability. The study found that older adults used a wider range of coping strateg...
KEY FINDING: Older adults reported a wider range of frequently used strategies and significantly more frequent engagement in activity pacing, seeking social support, and use of coping self-statements than did younger or middle-aged adults.
Nat Med, 2008 • January 1, 2008
The study demonstrates that significant recovery of hindlimb stepping can occur after severe spinal cord injury (SCI) in mice, even when direct connections from the brain to the legs are severed. This...
KEY FINDING: Pronounced functional recovery can occur after severe SCI without the maintenance or regeneration of direct projections from the brain past the lesion.
Cell Proliferation, 2008 • January 1, 2008
The study demonstrates that IL-6 and EGF stimulate proliferation of spinal cord-derived NPCs through distinct signalling pathways, JAK2/STAT3 and MAPK, respectively. Inhibition of JAK2 or EGFR prevent...
KEY FINDING: IL-6 and EGF independently stimulate the proliferation of spinal cord-derived NPCs via the JAK2/STAT3 and MAPK pathways, respectively.
The Journal of Neuroscience, 2007 • December 26, 2007
The study investigates the expression pattern and function of Advillin, an actin-binding protein, in the developing mouse nervous system, focusing on its role in somatosensory neurons. Using a novel A...
KEY FINDING: Advillin mRNA is almost exclusively expressed by craniofacial and dorsal root ganglia sensory neurons, with the exception of Me5 and Mo5 neurons.