The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

Spinal cord injury (SCI) is a devastating event that results in a wide range of physical impairments and disabilities. Recent studies have shown the utility of zebrafish as a model of neural regeneration following SCIs, including the proliferation and migration of various cell types and the involvement of various progenitor cells. More in-depth studies are needed to fully understand the neural regeneration mechanisms, proteins, and signaling pathways involved in the complex interactions between the SCI microenvironment and transplanted cells in non-mammals, particularly in the zebrafish model, which could, in turn, lead to new therapeutic approaches to treat SCIs in humans and other mammals.

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  Zebrafish, on the other hand, has strong neural regeneration abilities from the embryonic to adult stages.
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  Recent research has shed light on various cellular and molecular mechanisms involved in their regenerative abilities, including the activation of specific signaling pathways and the role of glial cells.
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  Recent studies by Cui et al. (2021) showed that neuropeptide Y (NPY) expression in motor neurons promoted descending axonal regeneration and locomotor recovery in adult zebrafish after an SCI [136].