Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury

This study investigates how a protein called fidgetin affects the regrowth of nerve fibers (axons) after spinal cord injury. Fidgetin is an enzyme that cuts microtubules, which are essential for axon growth and movement. The researchers found that depleting fidgetin promotes axon regeneration after spinal cord injury, while also increasing the expression of a protein called end binding protein 3 (EB3). The study suggests that fidgetin can be a target for new therapies to promote axon regeneration after spinal cord injury, revealing a mechanism by which fidgetin cuts specific microtubules.

• 1
  Depletion of fidgetin enhances axon regeneration after spinal cord injury and increases the expression of end binding protein 3 (EB3).
• 2
  Fidgetin interacts with EB3 and trims tyrosinated tubulins, which are components of microtubules, thereby affecting axonal regrowth and branching.
• 3
  Fign depletion enables greater amounts of Tyr-tubulin to break through the T-zone into the P-domain.