Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury

This study investigates the potential of bone marrow mesenchymal stem cells (BMSCs) to improve recovery after spinal cord injury (SCI) in rats. The researchers transplanted BMSCs intravenously into rats with SCI and observed their effect on nerve function and the expression of specific proteins in the spinal cord. The transplantation of BMSCs was found to improve neurological function in the rats over a period of five weeks. This improvement was assessed using the Basso-Beattie-Bresnahan (BBB) scoring system, which measures locomotor function. Furthermore, the study found that BMSCs promote the expression of choline acetyltransferase, glutamic acid decarboxylase, and synapsins in the damaged spinal cord. These substances are important for nerve cell communication and function.

• 1
  Intravenously transplanted bone marrow mesenchymal stem cells can migrate to the injured spinal cord of rats.
• 2
  Bone marrow mesenchymal stem cells promote the expression of choline acetyltransferase, glutamic acid decarboxylase, and synapsins in the damaged spinal cord.
• 3
  Transplantation of bone marrow mesenchymal stem cells improved nerve function in rats with spinal cord injury, as indicated by increased Basso-Beattie-Bresnahan scores.