Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 981-990 of 2,298 results
Nature Communications, 2021 • December 3, 2021
This study identifies a subpopulation of injury-induced intraspinal serotonergic neurons (ISNs) in zebrafish that promotes axon regrowth and locomotor recovery after spinal cord injury (SCI). These ISN...
KEY FINDING: Injury induces a specialized group of intraspinal serotonergic neurons (ISNs) at the injury site.
Translational Neuroscience, 2021 • January 1, 2021
This review discusses the importance of neurotrophic factors in treating spinal cord injuries (SCI) and the challenges associated with their delivery. It emphasizes that neurons need these factors to ...
KEY FINDING: Sustained delivery of exogenous neurotrophic factors is necessary to promote neural repair and functional recovery after SCI. The most commonly used exogenous neurotrophic factors include BDNF, neurotrophin-3 (NT-3), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF), and glial cell-derived neurotrophic factor (GDNF).
Neural Regeneration Research, 2022 • December 10, 2021
This review discusses the potential of in vivo neuronal reprogramming as a therapeutic strategy for spinal cord injury (SCI). The review summarizes reports on in vivo neuronal reprogramming in the spi...
KEY FINDING: Sox2 has been shown to reprogram astrocytes and NG2 glia into proliferating neuroblasts, which can further differentiate into mature neurons with additional treatments.
Frontiers in Immunology, 2021 • December 2, 2021
This review discusses the dual role of inflammation and glial scar formation in spinal cord injury (SCI) prognosis. While early inflammation is beneficial for clearing debris, persistent inflammation...
KEY FINDING: Early inflammatory responses after SCI can be beneficial for clearing debris and elevating neurotrophic factors. However, sustained inflammation leads to the release of inflammatory cytokines and reactive oxygen species, causing further damage.
Trends Mol Med, 2022 • February 1, 2022
The development of new therapies for pain treatment is challenging, but human DRG neurons and iPSC-SNs offer promise. These systems more closely mimic human physiology compared to rodent DRG neurons a...
KEY FINDING: Human and rodent DRG neurons exhibit significant functional and physiological differences, particularly in sodium channel composition and action potential properties, suggesting human DRG neurons may be a more clinically relevant model for pain studies.
Cells, 2021 • November 25, 2021
Spinal cord injury leads to irreversible functional impairment due to neuronal loss and disrupted neuronal connections. Neural stem cell (NSC) therapy is a promising pre-clinical therapeutic strategy ...
KEY FINDING: Host axons regenerate into spinal NSC grafts placed into sites of SCI, forming synapses with the graft.
Cells, 2021 • November 27, 2021
This study investigates the molecular mechanisms underlying the glial-biased differentiation of ependymal cells after spinal cord injury (SCI) by analyzing their RNA profiles before and after injury. ...
KEY FINDING: Ependymal cells activate STAT3 and ERK/MAPK signaling pathways post-spinal cord injury, indicating a response to the injury at the molecular level.
Biomedicines, 2021 • December 16, 2021
This study presents a combinatorial tissue-engineered strategy for treating spinal cord injuries using a hyaluronic acid scaffold, polypyrrole-coated fibers, PuraMatrix hydrogel, human induced neural ...
KEY FINDING: PuraMatrix hydrogel (PM) preserves iNPC viability, and curcumin (CURC) reduces apoptosis and enhances neurite outgrowth.
International Journal of Molecular Sciences, 2021 • December 12, 2021
Various biomaterials and fabrication techniques have been developed to construct 3D scaffolds suitable for the promotion of nerve injury repair. Many bio-scaffolds have been investigated for therapeut...
KEY FINDING: Combining the appropriate cell/exosome and scaffold type may thus achieve tissue repair and regeneration with safety and efficacy sufficient for routine clinical application.
Brain, 2022 • January 4, 2022
The study demonstrates that Celsr2, highly expressed in spinal motor neurons, inhibits axon regeneration. Inactivating Celsr2 in mice and human motor neurons promotes axon growth, fasciculation, and f...
KEY FINDING: Celsr2 knockout promotes axon regeneration and fasciculation in mouse cultured spinal explants and cultured Celsr2 mutant motor neurons extend longer neurites and larger growth cones.