Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 971-980 of 2,298 results
Science, 2021 • November 12, 2021
This study explores the use of peptide amphiphile supramolecular polymers with two distinct signals to promote recovery from spinal cord injury (SCI) in a mouse model. By tuning the internal motions o...
KEY FINDING: Intensifying molecular motions within bioactive scaffolds, achieved through specific mutations, significantly enhances recovery from spinal cord injury in mice.
International Journal of Molecular Sciences, 2021 • November 7, 2021
This review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins. The most important clinical application of L...
KEY FINDING: UFH, LMWH, and synthetic pentasaccharides are used to prevent and cure thromboembolic events, but UFH is also a modulator of cell adhesion, migration, communication, proliferation, and differentiation.
Neural Regen Res, 2022 • June 1, 2022
This study aimed to identify key genes and pathways involved in axon regeneration after spinal cord injury (SCI) in zebrafish to provide new targets for mammalian SCI treatment. RNA sequencing data an...
KEY FINDING: Zebrafish spontaneously recovered 44% of their swimming ability within the subacute phase (2 weeks) after spinal cord injury.
Neural Regeneration Research, 2022 • November 12, 2021
The study investigated the neuroprotective potential of APP96-110 peptide, alone and in combination with human mesenchymal stromal cells (hMSCs), following spinal cord injury (SCI) in rats. While APP9...
KEY FINDING: mAPP96-110 alone, and APP96-110 in combination with both viable and non-viable hMSCs significantly reduced cyst size compared to SCI alone.
Bioactive Materials, 2022 • January 1, 2022
This study utilizes single-cell RNA sequencing to investigate the molecular mechanisms underlying MSC-mediated bone regeneration in different osteogenic microenvironments, specifically focusing on hyd...
KEY FINDING: HA scaffolds induce bone formation through a process similar to endochondral ossification, activating TGF-β, PTHrP, and BMP signaling pathways sequentially.
Cells, 2021 • October 30, 2021
This review provides a detailed overview of the local and systemic alterations due to TSCI and TBI, which severely affect multiple physiological systems. It raises awareness of the impact of TSCI–TBI ...
KEY FINDING: TSCI and TBI interact bidirectionally, impacting cognitive and sensorimotor outcomes.
Cells, 2021 • November 3, 2021
This review discusses recent advances in cell-based experimental strategies aimed at supporting or restoring function to the injured spinal cord, focusing on regenerative mechanisms relevant to clinic...
KEY FINDING: Transplantation of mesenchymal stem cells (MSCs) into the injured spinal cord can increase the number of M2 macrophages and reduce the number of M1 macrophages, leading to functional recovery in animal models.
Cells, 2021 • November 16, 2021
This review explores the potential of combining stem cells and 3D bioprinted scaffolds for spinal cord injury (SCI) treatment. Current SCI therapies are inadequate, creating a need for new approaches....
KEY FINDING: Stem cells have self-renewing capabilities making them suitable for SCI treatment, however, their application is limited due to ethical issues, immune rejection and limited sources.
Cells, 2021 • November 18, 2021
This review focuses on current research related to the secretome and the lesion-induced secretome and their roles in modulating spinal cord injury symptoms and functional recovery. MSCs are likely to ...
KEY FINDING: MSCs secrete a variety of soluble anti-inflammatory molecules, including TNF-β1, IL-13, IL-18 binding protein, CNTF, NT-3, IL-10, and IL-27, suggesting a significant immunoregulatory role.
J Vis Exp, null • June 24, 2022
This study describes methods to quantify swim endurance and swim behavior in adult zebrafish using a swim tunnel. Zebrafish are subjected to increasing water current velocities to measure swim enduran...
KEY FINDING: Wild-type zebrafish swam for 41 minutes before exhaustion, establishing a baseline for motor function.