Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 961-970 of 2,298 results
Frontiers in Cellular Neuroscience, 2021 • September 28, 2021
This study investigates the therapeutic potential of bone marrow mesenchymal stem cell-derived exosome-educated macrophages (EEM) in promoting functional healing after spinal cord injury (SCI). The fi...
KEY FINDING: EEM treatment effectively promoted the angiogenic activity of HUVECs and axonal growth in cortical neurons in vitro.
Cell Death Discovery, 2021 • October 8, 2021
The study demonstrates that transplanting NSCs modified to express NGF under hypoxic conditions can improve recovery after SCI in rats. The 5HRE-NGF-NSCs group showed better locomotor recovery, increa...
KEY FINDING: 5HRE-NGF-NSCs effectively improve animal motor function.
Cells, 2021 • September 28, 2021
This study investigated the restorative effects of human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM) on spinal cord injury (SCI) in a rat model. The results demo...
KEY FINDING: hAF-MSCs increased the expression of doublecortin (DCX), a marker of neurogenesis, significantly more than the injury group, indicating enhanced nerve regeneration.
npj Regenerative Medicine, 2021 • January 1, 2021
This study investigates the early transcriptome changes after spinal cord injury (SCI) in Xenopus laevis larvae to identify signals triggering neural stem progenitor cell (NSPC) proliferation. The ana...
KEY FINDING: mTORC1 is rapidly and transiently activated after spinal cord injury (SCI) in Xenopus laevis larvae.
Biomaterials Research, 2021 • September 15, 2021
This study investigates a 3D-printed PLA cage/Biogel scaffold as a carrier for BMP-2 to enhance bone regeneration in rat calvarial defect and ectopic ossification models. The scaffold was designed for...
KEY FINDING: The in vitro results showed the cage/Biogel scaffold released BMP-2 with an initial burst release and followed by a sustained slow-release pattern, maintaining its osteoinductivity for at least 14 days.
European Journal of Histochemistry, 2021 • August 13, 2021
This study evaluated the impact of unacylated ghrelin (UnAG) on peripheral nerve regeneration in mice after crush and transection injuries. The researchers used transgenic mice with overexpression of ...
KEY FINDING: Healthy mice with elevated UnAG levels showed differences in nerve structure compared to normal mice, suggesting a role for UnAG in nerve development. Specifically, UnAG median nerves have a higher density and smaller myelinated fibres than WT nerves.
WIREs Mechanisms of Disease, 2021 • March 1, 2021
The spinal cord is divided into motor and somatosensory circuits. Sensory stimuli are processed by dorsal interneurons (dIs) in the dorsal spinal cord, which relay information to the brain or motor ci...
KEY FINDING: Dorsal interneuron fates are specified by mechanisms distinct from those in the ventral spinal cord.
The Journal of Neuroscience, 2021 • December 15, 2021
This study investigates how modulation of both intrinsic (Pten deletion) and extrinsic (RhoA/RhoC deletion) factors affects axon regeneration and rewiring after spinal cord injury (SCI). The results i...
KEY FINDING: Genetic deletion of RhoA and RhoC suppresses axon retraction or dieback after spinal cord injury.
Neural Regen Res, 2015 • August 1, 2015
This study investigated the neuroprotective effects of Panax notoginseng saponins (PNS) on spinal cord injury (SCI) recovery in rats. The study found that PNS treatment improved hindlimb motor functio...
KEY FINDING: The BBB score, indicating locomotor function, was significantly higher in rats treated with PNS compared to those treated with saline from 7 to 30 days after injury.
Neural Regeneration Research, 2015 • August 1, 2015
This study investigated the effect of Buyang Huanwu decoction (BYHWD) on the Notch signaling pathway in rats with spinal cord injury (SCI). The results showed that BYHWD increased the expression of No...
KEY FINDING: The expression of Notch1 was increased in the BYHWD group compared with controls at 7, 14, and 28 days after injury.