Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 311-320 of 2,298 results
Regeneration, 2014 • June 11, 2014
The study investigates the transcriptional response of regenerating DRG neurons and associated cells to signaling from the blastema in axolotls. A DRG−blastema co-culture model was used to test the hy...
KEY FINDING: Over 1500 genes change expression in DRG and the nerve trunk during the first 5 days of culture, indicating nerve recovery and regeneration after dissection.
Neural Regen Res, 2012 • February 1, 2012
This study investigates NG2 expression in a rat model of acute T10 spinal cord injury using clamp method to induce injury. NG2 expression was detected using immunohistochemical staining and western bl...
KEY FINDING: Acute T10 spinal cord injury in rats leads to increased NG2 protein expression in damaged areas.
Neural Regeneration Research, 2012 • February 1, 2012
This study analyzed differentially expressed proteins between motor and sensory nerves using two-dimensional gel electrophoresis and mass spectrometry. The results revealed differential expression of ...
KEY FINDING: Differential expression of 11 proteins was observed between motor and sensory nerves.
Neural Regen Res, 2012 • February 1, 2012
This study investigates the effect of 7, 8-dihydroxycoumarin on peripheral nerve regeneration and functional recovery in a mouse model of sciatic nerve injury. The results indicate that 7, 8-dihydroxy...
KEY FINDING: 7, 8-dihydroxycoumarin upregulated GAP-43 protein expression in the L4-6 segments of the injured side in mice with sciatic nerve injury.
Neural Regeneration Research, 2015 • January 1, 2015
This review discusses the potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treating spinal cord injury. It addresses potential mechanisms such as neuronal ...
KEY FINDING: iPSC-derived NSCs can differentiate into neurons, astrocytes, and oligodendrocytes after transplantation into animal models of SCI.
Neural Regeneration Research, 2015 • January 1, 2015
This study introduces a novel goat model for cauda equina injury and repair, addressing the limitations of rat models. The goat model allows for surgical repair and monitoring of outcomes using electr...
KEY FINDING: The study successfully established a goat experimental model that mimics human cauda equina injury, allowing for surgical repair and outcome monitoring.
Neural Regeneration Research, 2015 • January 1, 2015
This study examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after spinal cord hemisection injury. The fin...
KEY FINDING: Biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection.
Stem Cells International, 2015 • January 6, 2015
The paper details a method for organotypic longitudinal spinal cord slice culture, highlighting its advantages for studying spinal cord regeneration and stem cell therapies. The technique preserves th...
KEY FINDING: The longitudinal spinal cord organotypic slice culture allows the observation of long fiber trajectory, formation of new connections, and neurorepair processes occurring after the spinal cord injury.
Neural Plasticity, 2015 • March 2, 2015
This study investigates the anatomical changes in the dopaminergic system of lampreys following complete spinal cord injury and during the recovery period, focusing on dopaminergic innervation, cell n...
KEY FINDING: Numbers of dopaminergic cells were recovered rostrally and caudally to the site of injury, indicating a regeneration of the cell population after the initial injury.
BioMed Research International, 2015 • January 5, 2015
The study investigated the therapeutic potential of skin-derived precursor cells (SKPs) in a rat model of cerebral ischemia, finding that SKPs transplantation improved behavioral measures of neurologi...
KEY FINDING: SKPs transplantation could improve the behavioral measures of neurological deficit.