Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 301-310 of 2,298 results
Neural Regeneration Research, 2014 • December 1, 2014
This study examined the effects of oral intake of thermomineral water on nerve regeneration in a mouse model of spinal cord injury. The results indicate that thermomineral water promotes locomotor rec...
KEY FINDING: Mice drinking thermomineral water showed significantly better locomotor recovery at 4, 8, and 12 weeks post-injury compared to the control group.
Neural Regen Res, 2014 • December 1, 2014
This study explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. Our findings indicate that hyperbaric oxy...
KEY FINDING: Hyperbaric oxygen therapy reduces apoptosis in the injured spinal cord tissue of rats.
Neural Regeneration Research, 2014 • December 1, 2014
This study investigated the potential of combining mild hypothermia with a PLGA scaffold seeded with NgR-silenced neural stem cells and Schwann cells to treat spinal cord injury in rats. The results s...
KEY FINDING: Mild hypothermia combined with the NgR-silenced cell scaffold significantly improved hindlimb motor function in rats after spinal cord injury, as evidenced by inclined plate tests and modified BBB scores.
Neural Regeneration Research, 2014 • December 1, 2014
Human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor ...
KEY FINDING: Human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells.
Journal of Advanced Research, 2014 • January 1, 2014
This review discusses the isolation, characterization, in vitro expansion, and use of NSCs in cell replacement therapies for neurodegenerative diseases and strokes. NSCs can be sourced from skin, ESCs...
KEY FINDING: NSCs can be isolated from various sources including skin, embryonic stem cells, bone marrow and adult nervous systems.
BioMed Research International, 2015 • January 1, 2015
The study investigates the potential of human dental follicle cells (hDFCs) combined with aligned electrospun PCL/PLGA material (AEM) as a therapeutic strategy for spinal cord defects (SCD). In vitro ...
KEY FINDING: Human dental follicle cells (hDFCs) can be induced to express neurogenic markers and are a potential resource for neural regeneration.
Neural Regen Res, 2012 • June 1, 2012
This study used bibliometric analyses to quantitatively and qualitatively investigate research trends in studies of stem cell transplantation for treating spinal cord injury. BMMSCs and ESCs are widel...
KEY FINDING: Bone marrow mesenchymal stem cells (BMMSCs) and embryonic stem cells (ESCs) are widely studied for treating spinal cord injury.
Neural Regen Res, 2012 • May 1, 2012
This study investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the cur...
KEY FINDING: TNF-α contributes to the induction of targeted migration of MSCs towards damaged sites in the spinal cord, and activates the extracellular signal-regulated kinase and p38 pathways in MSCs.
Neural Regen Res, 2012 • May 1, 2012
This study demonstrates that electroacupuncture promotes the proliferation of endogenous neural stem cells (eNSCs) and oligodendrocytes in rats with spinal cord injury (SCI). The results suggest that ...
KEY FINDING: Electroacupuncture significantly increased the number of BrdU-positive cells (indicating cell proliferation) in rats with SCI, particularly at spinal cord tissue 15 mm away from the injury center in both rostral and caudal directions.
Neural Regeneration Research, 2012 • April 1, 2012
This paper explores the evolutionary aspects of spinal cord injury (SCI) repair, focusing on why lower vertebrates can regenerate their spinal cords while higher vertebrates cannot. The study investig...
KEY FINDING: Lower vertebrates and higher vertebrates in embryonic development possess the capability of spinal cord regeneration, but this capacity diminishes with evolution.