Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,281-1,290 of 2,298 results
Int. J. Mol. Sci., 2023 • November 7, 2023
Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance, making them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. An increased unders...
KEY FINDING: MSCs are passive targets in inflammatory conditions, becoming impaired and losing their immunomodulatory function.
Molecular Neurobiology, 2024 • November 28, 2023
This study investigates the potential of combining TUDCA with BMSC transplantation for treating SCI in rats. The research aims to assess whether TUDCA can improve BMSC survival and efficacy within the...
KEY FINDING: TUDCA significantly enhanced BMSC viability and reduced apoptosis (assessed by Annexin V-FITC, TUNEL, Bax, Bcl-2, and Caspase-3) as well as oxidative stress (assessed by ROS, GSH, SOD, and MDA) both in vitro and in vivo.
Veterinary and Animal Science, 2023 • October 30, 2023
This case report investigated the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog with an injury in the...
KEY FINDING: AF-MSC transplantation improved hind limb movement in a dog with a lumbar spinal cord injury.
Adv Pharm Bull, 2023 • October 20, 2023
The study investigates the potential of human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM) to promote neuroblast and astrocyte production and functional recovery ...
KEY FINDING: MSCs increased the number of endogenous DCX-positive cells and decreased the number of GFAP-positive cells via juxtacrine and paracrine mechanisms.
Heliyon, 2023 • October 27, 2023
This study evaluated the regulatory effect of Tetramethylpyrazine (TMP) on the spinal cord injury (SCI) rat model and clarified the neuroprotective mechanism of TMP on SCI. The study results presented...
KEY FINDING: TMP promotes angiogenesis, nerve regeneration, and repair of nerve defects in SCI rats.
Regenerative Therapy, 2023 • October 26, 2023
This study investigates the potential of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation into cerebrospinal fluid for treating acute spinal cord injury (SCI) in a canine model...
KEY FINDING: MRI revealed that the signal intensity reduced over time in both BM-MNCetreated and control groups.
Advanced Science, 2024 • November 30, 2023
This study introduces a novel strategy for treating spinal cord injury (SCI) by targeting the recovery of mitochondrial energy metabolism through a combination of ROS scavenging and energy supplementa...
KEY FINDING: Ligand-screened cerium-based MOFs with creatine loading and polydopamine encapsulation (Gel-Cr/Ce@PDA) regulate macrophage phenotypes towards M2 via metabolic reprogramming.
Advanced Healthcare Materials, 2024 • December 16, 2023
This study presents a novel thermoresponsive hydrogel that encapsulates dental pulp stem cells (DPSCs) and delivers hydrogen sulfide (H2S) for spinal cord injury (SCI) repair. The hydrogel incorporate...
KEY FINDING: The PF-OMSF@JK composite hydrogel significantly improves in vivo SCI regeneration in Sprague–Dawley rats through a reduction in inflammation and neuronal differentiation of the incorporated stem cells.
Bioactive Materials, 2024 • January 1, 2024
This study investigates the therapeutic potential of exosomes derived from EGFR+NSCs for treating spinal cord injury (SCI). The findings demonstrate that local delivery of EGFR+NSCs-Exos promotes neur...
KEY FINDING: EGFR+NSCs-Exos can effectively promote neurite regrowth in the injury site of spinal cord-injured mice and improve their neurological function recovery.
International Journal of Nanomedicine, 2023 • December 6, 2023
Spinal cord injury (SCI) treatment remains a significant clinical challenge, but neural tissue engineering offers a promising therapeutic approach through the implantation of functionalized electrocon...
KEY FINDING: Glial fibrosis and fluid-filled cysts impede electrical signaling and stimulus conduction in spinal cord tissue, hindering neural regeneration.