Regenerative Medicine Research

KEY FINDING: Hypoxic preconditioning enhances the therapeutic function of MSC-derived sEVs for IVD regeneration.

KEY FINDING: Myelin debris clearance, axon regeneration, and function recovery were all faster in CD47−/− mice than in wild type mice.

KEY FINDING: MSCs transplantation protects nerves through anti-inflammatory, anti-oxidant, anti-apoptotic, and increased blood flow mechanisms.

KEY FINDING: SLRPs, including chondroadherin, fibromodulin, lumican, and prolargin, are enriched in rodent and human CNS lesions but not in zebrafish.

KEY FINDING: The review highlights novel targets for improving direct pro-neural reprogramming, including mitochondria, nucleoli, and G-quadruplexes.

KEY FINDING: Stem cell sheets improve motor and sensory function recovery in SCI animal models compared to untreated rats.

KEY FINDING: Engineered mitochondrial compounds (Mito-Tpp-CAQK) significantly enhanced macrophage phagocytosis of myelin debris both in vitro and in vivo.

KEY FINDING: AhR activation in DRG neurons inhibits axon regeneration after nerve injury.

KEY FINDING: IL-4/G-CSF polarization reprograms bone marrow neutrophils (BMNs), causing them to upregulate alternative activation markers and produce cytoprotective and growth factors, akin to zymosan-modulated counterparts.

KEY FINDING: DPSCs have significant potential in neural tissue engineering due to easy isolation, multidifferentiation potential, low immunogenicity, and low transplant rejection rate.