Regenerative Medicine Research

KEY FINDING: HGF treatment after SCI promotes vascularization and suppresses inflammatory responses, creating a more favorable environment for cell transplantation.

KEY FINDING: Parthenolide significantly enhanced neurite extension concentration-­dependently with maximum effects at 0.5 and 1 nM.

KEY FINDING: A Regeneration Classifier was developed that can predict the regenerative potential of diverse neuronal types based on their single-cell transcriptomes.

KEY FINDING: Knockdown of MLL1 in SCAPs increases the expression of neural markers such as NeuroD, NCAM, TH, βIII-tubulin and Nestin, promoting neuron-like cell formation.

KEY FINDING: Spinal cord organoids dynamically simulate neural tube formation and exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal axes.

KEY FINDING: SCI can decrease the phosphory­lated (p)/total (t)‑GSK‑3β ratio, which leads to an increase in apoptosis, whereas treatment with GSK‑3 inhibitors can promote neurogenesis.

KEY FINDING: DPSC-CM effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury.

KEY FINDING: MiR-28-5p directly targets Notch1, facilitating neuronal differentiation of BMSCs in vitro.

KEY FINDING: The soluble receptor decoy AXER-204 was safe and well-tolerated in a first-in-human clinical trial for chronic cervical SCI.

KEY FINDING: The HES rapidly expanded 80-fold in size upon absorbing 2.6 million hAESCs within 2 minutes, representing over a 400% increase in loading capacity versus controls.