Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,251-1,260 of 2,298 results
Int. J. Mol. Sci., 2023 • September 20, 2023
Stem cell therapy holds promise for SCI treatment by potentially revolutionizing damaged neural tissue repair and regeneration. As research progresses and challenges are addressed, stem cell therapy c...
KEY FINDING: Stem cell therapy offers hope by replacing lost neurons, promoting axonal growth, remyelinating damaged axons, modulating immune response, and creating a permissive environment for functional recovery.
Regeneration, 2017 • January 18, 2017
This study investigates the role of the JAK-STAT pathway in spinal cord regeneration in Xenopus laevis, comparing regenerative and non-regenerative stages after spinal cord injury. Transcriptome analy...
KEY FINDING: Regenerative tadpoles exhibit an early and transient activation of the JAK-STAT pathway following spinal cord injury.
Pharmaceutics, 2023 • August 31, 2023
This study explores the potential of electrospun self-assembling peptide (SAP) scaffolds for neural stem cell (NSC) transplantation in spinal cord regeneration. The scaffolds are designed to mimic the...
KEY FINDING: The addition of both SDS and HYDROSAP led to the formation of tiny, fibrous, and uniform nanofibers without beads-on-string morphology and with a very narrow diameter distribution between 100–300 nm.
Theranostics, 2023 • August 28, 2023
This study introduces a novel three-dimensional (3D) nanofibrous sponge (NS) scaffold, created using directional electrospinning and gas-foaming, to promote neural stem cell (NSC) differentiation and ...
KEY FINDING: The 3D NSs promoted cell infiltration, induced cell alignment, and enhanced neuronal differentiation and maturation of NSCs through cellular adhesion molecule pathways.
BMC Veterinary Research, 2023 • September 27, 2023
This study successfully isolated, propagated, and differentiated canine NSPCs derived from the cervical spinal cord in adult canines, demonstrating their potential for spinal cord regeneration. The is...
KEY FINDING: Canine cervical spinal cord-derived NSPCs can be isolated and propagated for at least 10 passages.
ibrain, 2022 • August 1, 2022
This review discusses the potential of endogenous neural stem cells (ENSCs) in treating spinal cord injury (SCI). It addresses the challenges related to ENSC activation and proliferation due to the oc...
KEY FINDING: ENSCs are located in the ependymal region of the central canal and can differentiate into various nerve cells after SCI.
Advanced Science, 2023 • October 3, 2023
This study introduces a pro-regenerative system, miR-26a@SPIONs-OECs, designed to provide external bioactive cues to encourage linear axonal growth, moderate local astrocyte activation, and ultimately...
KEY FINDING: miR-26a@SPIONs-OECs, when stimulated by a magnetic field, release extracellular vesicles rich in miR-26a, which inhibits PTEN and GSK-3β signaling pathways in neurons, promoting axon growth.
Frontiers in Cellular Neuroscience, 2023 • September 27, 2023
This study assessed the efficacy of daily oral boldine administration in a rodent model of prolonged denervation and delayed nerve repair. Boldine administration preserved the evoked muscle for 2 week...
KEY FINDING: Daily boldine administration significantly enhanced an evoked response in the tibialis anterior muscle at 2 weeks after common peroneal nerve transection.
Neural Regeneration Research, 2024 • September 4, 2023
This review discusses regenerative medicine strategies for chronic complete spinal cord injury, highlighting the challenges and potential therapeutic approaches. The authors emphasize the need for com...
KEY FINDING: Chronic complete SCI requires a combination of therapies to overcome multiple inhibitory factors and promote functional recovery.
Neural Regeneration Research, 2024 • April 1, 2024
This study tested a new way to fix long-gap peripheral nerve injury by combining a 3D composite conduit with human umbilical cord mesenchymal stem cell-derived exosomes. The results showed that this m...
KEY FINDING: Transplantation of the 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes promoted peripheral nerve regeneration and restoration of motor function, similar to autograft transplantation.