Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,241-1,250 of 2,298 results
Journal of Neurotrauma, 2023 • December 1, 2023
This study investigates the recovery of forearm and fine digit function after chronic spinal cord injury (SCI) in rats, using a novel treatment strategy that simultaneously blocks chondroitin sulfate ...
KEY FINDING: The combined treatment of ISP and PNNi significantly improved forelimb locomotor function in chronically injured rats.
Journal of Translational Medicine, 2023 • August 1, 2023
This study investigated the effects of acetylglutamine (NAG) on motor and sensory recovery after brachial plexus root avulsion (BPRA) in rats. BPRA leads to significant motor neuron death and loss of ...
KEY FINDING: NAG significantly accelerated the recovery of motor function in the injured forelimbs of rats following BPRA, as evidenced by improved scores in grooming tests, cylinder tests, and food pellet-taking tests.
Methods Mol Biol, 2024 • January 1, 2024
This paper describes methods for performing complete spinal cord transections in zebrafish and assessing functional and cellular recovery during regeneration. Swim endurance is quantified as a central...
KEY FINDING: Zebrafish regain swim capacity within 8 weeks of spinal cord injury, indicating successful regeneration.
Molecular Neurobiology, 2024 • September 6, 2023
The study investigated the role of the transcription factor Ets1 in spinal cord development and regeneration, finding it highly expressed during the embryonic period and decreasing with development. K...
KEY FINDING: Ets1 is highly expressed in the spinal cord during the embryonic period and decreases during development.
Acta Biochim Biophys Sin, 2023 • September 6, 2023
This study investigates the role of Fucosyltransferase 9 (Fut9) in promoting neuronal differentiation and functional recovery after spinal cord injury (SCI). The researchers found that Wnt4 upregulate...
KEY FINDING: Wnt4 upregulates Fut9 expression through the β-catenin signaling pathway, indicating that Fut9 may be involved in neuronal differentiation by Wnt4.
Cells, 2023 • August 28, 2023
This review comprehensively examines methodologies to induce the differentiation of MSCs into IVD cells for regenerative therapies for IDD, focusing on molecules, scaffolds, and environmental factors....
KEY FINDING: TGF-β superfamily members and GDF5 and 6 played key roles in MSC differentiation into NPC-like cells, with BMP-7 and GDF6 being potentially the most effective.
J. Biol. Chem., 2023 • September 9, 2023
The study identifies a growth-promoting amino-terminal fragment of Nogo-A that is released by proteolysis and upregulated after injury. This fragment promotes axon regeneration in vitro and interacts ...
KEY FINDING: An amino-terminal fragment of Nogo-A (aa 1-213) is produced by proteolysis near G214-N215 and its levels are increased after axotomy.
Neural Regeneration Research, 2024 • July 20, 2023
Spinal cord injury (SCI) involves primary and secondary injuries. Secondary injuries are complex with no effective treatment developed yet, affecting neural cells and surrounding structures. Regenerat...
KEY FINDING: Stem cell-derived EVs have been shown to have many of the same regenerative properties as being MSCs, without the many challenges associated with stem cell therapy.
Am J Case Rep, 2015 • October 27, 2015
This case report investigated the neuroregenerative potential of oxandrolone in a patient with Charcot-Marie-Tooth disease type 1 (CMT1). The patient received oxandrolone and underwent exercise traini...
KEY FINDING: The patient gained 5.0 kg of lean body mass after the 3-month therapy.
Int. J. Mol. Sci., 2023 • September 11, 2023
To develop effective therapies, it is vital to have a comprehensive understanding of the complex interplay between various cell types, molecular pathways, and signaling mechanisms that play major role...
KEY FINDING: Zebrafish, on the other hand, has strong neural regeneration abilities from the embryonic to adult stages.